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Papers on “gut microbiome brain axis mental health depression”

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1. The Microbiota-Gut-Brain Axis

   John F. Cryan, Kenneth J. O’Riordan, Caitlin S.M. Cowan, et al. · 2019 · Physiological Reviews · 5,200 cites

   The importance of the gut-brain axis in maintaining homeostasis has long been appreciated. However, the past 15 yr have seen the emergence of the microbiota (the trillions of microorganisms within and on our bodies) as one of the key regulators of gut-brain function and has led to the appreciation of the importance of a distinct microbiota-gut-brain axis. This axis is gaining ever more traction in fields investigating the biological and physiological basis of psychiatric, neurodevelopmental, age-related, and neurodegenerative disorders. The microbiota and the brain communicate with each other via various routes including the immune system, tryptophan metabolism, the vagus nerve and the enter

2. The role of short-chain fatty acids in microbiota–gut–brain communication

   Boushra Dalile, Lukas Van Oudenhove, Bram Vervliet, et al. · 2019 · Nature Reviews Gastroenterology & Hepatology · 3,388 cites

3. Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease

   Allison Agus, Julien Planchais, Harry Sokol · 2018 · Cell Host & Microbe · 3,164 cites

4. Gut microbiome alterations in Alzheimer’s disease

   N. Vogt, Robert L. Kerby, Kimberly A. Dill‐McFarland, et al. · 2017 · Scientific Reports · 2,165 cites

   Alzheimer's disease (AD) is the most common form of dementia. However, the etiopathogenesis of this devastating disease is not fully understood. Recent studies in rodents suggest that alterations in the gut microbiome may contribute to amyloid deposition, yet the microbial communities associated with AD have not been characterized in humans. Towards this end, we characterized the bacterial taxonomic composition of fecal samples from participants with and without a diagnosis of dementia due to AD. Our analyses revealed that the gut microbiome of AD participants has decreased microbial diversity and is compositionally distinct from control age- and sex-matched individuals. We identified phylum

5. The Genus Alistipes: Gut Bacteria With Emerging Implications to Inflammation, Cancer, and Mental Health

   Bianca J. Parker, Pamela A. Wearsch, A.C.M. Veloo, et al. · 2020 · Frontiers in Immunology · 1,753 cites

   Alistipes is a relatively new genus of bacteria isolated primarily from medical clinical samples, although at a low rate compared to other genus members of the Bacteroidetes phylum, which are highly relevant in dysbiosis and disease. According to the taxonomy database at The National Center for Biotechnology Information, the genus consists of thirteen species: A. finegoldii, A. putredinis, A. onderdonkii, A. shahii, A. indistinctus, A. senegalensis, A. timonensis, A. obesi, A. ihumii, A. inops, A. megaguti, A. provencensis, and A. massiliensis. Although typically isolated from the human gut microbiome various species of this genus have been isolated from patients suffering from appendicitis,

6. The Central Nervous System and the Gut Microbiome

   Gil Sharon, Timothy R. Sampson, Daniel H. Geschwind, et al. · 2016 · Cell · 1,565 cites

7. Gut/brain axis and the microbiota

   Emeran A. Mayer, Kirsten Tillisch, Arpana Gupta · 2015 · Journal of Clinical Investigation · 1,500 cites

   Tremendous progress has been made in characterizing the bidirectional interactions between the central nervous system, the enteric nervous system, and the gastrointestinal tract. A series of provocative preclinical studies have suggested a prominent role for the gut microbiota in these gut-brain interactions. Based on studies using rodents raised in a germ-free environment, the gut microbiota appears to influence the development of emotional behavior, stress- and pain-modulation systems, and brain neurotransmitter systems. Additionally, microbiota perturbations by probiotics and antibiotics exert modulatory effects on some of these measures in adult animals. Current evidence suggests that mu

8. The Brain-Gut-Microbiome Axis

   Clair R. Martin, Vadim Osadchiy, Amir Kalani, et al. · 2018 · Cellular and Molecular Gastroenterology and Hepatology · 1,294 cites

   The past decade has seen a paradigm shift in our understanding of the brain-gut axis.The exponential growth of evidence detailing the bidirectional interactions between the gut microbiome and the brain supports a comprehensive model that integrates the central nervous, gastrointestinal, and immune systems with this newly discovered organ.Data from preclinical and clinical studies have shown remarkable potential for novel treatment targets not only in functional gastrointestinal disorders but in a wide range of psychiatric and neurologic disorders, including Parkinson's disease, autism spectrum disorders, anxiety, and depression, among many others.Preclinical and clinical studies have shown b