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Research papers on Long COVID

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  3. Characterizing long COVID in an international cohort: 7 months of symptoms and their impact

    Hannah Davis, Gina Assaf, Lisa McCorkell, et al. · 2021 · EClinicalMedicine · 3,043 citations

    BACKGROUND: A significant number of patients with COVID-19 experience prolonged symptoms, known as Long COVID. Few systematic studies have investigated this population, particularly in outpatient settings. Hence, relatively little is known about symptom makeup and severity, expected clinical course, impact on daily functioning, and return to baseline health. METHODS: We conducted an online survey of people with suspected and confirmed COVID-19, distributed via COVID-19 support groups (e.g. Body Politic, Long COVID Support Group, Long Haul COVID Fighters) and social media (e.g. Twitter, Facebook). Data were collected from September 6, 2020 to November 25, 2020. We analyzed responses from 3762

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  5. Management of post-acute covid-19 in primary care

    Trisha Greenhalgh, Matthew Knight, Christine A’Court, et al. · 2020 · BMJ · 1,797 citations

    Management of covid-19 after the first three weeks is currently based on limited evidence Approximately 10% of people experience prolonged illness after covid-19 Many such patients recover spontaneously (if slowly) with holistic support, rest, symptomatic treatment, and gradual increase in activity Home pulse oximetry can be helpful in monitoring breathlessness Indications for specialist assessment include clinical concern along with respiratory, cardiac, or neurological symptoms that are new, persistent, or progressive the

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  7. Characterising long COVID: a living systematic review

    Melina Michelen, Lakshmi Manoharan, Natalie Elkheir, et al. · 2021 · BMJ Global Health · 989 citations

    Background While it is now apparent clinical sequelae (long COVID) may persist after acute COVID-19, their nature, frequency and aetiology are poorly characterised. This study aims to regularly synthesise evidence on long COVID characteristics, to help inform clinical management, rehabilitation strategies and interventional studies to improve long-term outcomes. Methods A living systematic review. Medline, CINAHL (EBSCO), Global Health (Ovid), WHO Global Research on COVID-19 database, LitCovid and Google Scholar were searched till 17 March 2021. Studies including at least 100 people with confirmed or clinically suspected COVID-19 at 12 weeks or more post onset were included. Risk of bias was

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  8. Long COVID or Post-acute Sequelae of COVID-19 (PASC): An Overview of Biological Factors That May Contribute to Persistent Symptoms

    Amy D. Proal, Michael B. VanElzakker · 2021 · Frontiers in Microbiology · 936 citations

    The novel virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic of coronavirus disease 2019 (COVID-19). Across the globe, a subset of patients who sustain an acute SARS-CoV-2 infection are developing a wide range of persistent symptoms that do not resolve over the course of many months. These patients are being given the diagnosis Long COVID or Post-acute sequelae of COVID-19 (PASC). It is likely that individual patients with a PASC diagnosis have different underlying biological factors driving their symptoms, none of which are mutually exclusive. This paper details mechanisms by which RNA viruses beyond just SARS-CoV-2 have be connected to long-term health

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  9. Autonomic dysfunction in ‘long COVID’: rationale, physiology and management strategies

    Melanie Dani, Andreas Dirksen, Patricia Taraborrelli, et al. · 2020 · Clinical Medicine · 762 citations

    The SARS-CoV-2 (COVID-19) pandemic has caused unprecedented morbidity, mortality and global disruption. Following the initial surge of infections, focus shifted to managing the longer-term sequelae of illness in survivors. 'Post-acute COVID' (known colloquially as 'long COVID') is emerging as a prevalent syndrome. It encompasses a plethora of debilitating symptoms (including breathlessness, chest pain, palpitations and orthostatic intolerance) which can last for weeks or more following mild illness. We describe a series of individuals with symptoms of 'long COVID', and we posit that this condition may be related to a virus- or immune-mediated disruption of the autonomic nervous system result

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  10. Long COVID: post-acute sequelae of COVID-19 with a cardiovascular focus

    Betty Raman, David A. Bluemke, Thomas F. Lüscher, et al. · 2022 · European Heart Journal · 684 citations

    Emerging as a new epidemic, long COVID or post-acute sequelae of coronavirus disease 2019 (COVID-19), a condition characterized by the persistence of COVID-19 symptoms beyond 3 months, is anticipated to substantially alter the lives of millions of people globally. Cardiopulmonary symptoms including chest pain, shortness of breath, fatigue, and autonomic manifestations such as postural orthostatic tachycardia are common and associated with significant disability, heightened anxiety, and public awareness. A range of cardiovascular (CV) abnormalities has been reported among patients beyond the acute phase and include myocardial inflammation, myocardial infarction, right ventricular dysfunction,

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  11. Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin

    Etheresia Pretorius, Maré Vlok, Chantelle Venter, et al. · 2021 · Cardiovascular Diabetology · 557 citations

    BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2)-induced infection, the cause of coronavirus disease 2019 (COVID-19), is characterized by acute clinical pathologies, including various coagulopathies that may be accompanied by hypercoagulation and platelet hyperactivation. Recently, a new COVID-19 phenotype has been noted in patients after they have ostensibly recovered from acute COVID-19 symptoms. This new syndrome is commonly termed Long COVID/Post-Acute Sequelae of COVID-19 (PASC). Here we refer to it as Long COVID/PASC. Lingering symptoms persist for as much as 6 months (or longer) after acute infection, where COVID-19 survivors complain of recurring fatigue or mu

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  12. Prevalence of symptoms, comorbidities, fibrin amyloid microclots and platelet pathology in individuals with Long COVID/Post-Acute Sequelae of COVID-19 (PASC)

    Etheresia Pretorius, Chantelle Venter, Gert Jacobus Laubscher, et al. · 2022 · Cardiovascular Diabetology · 257 citations

    BACKGROUND: Fibrin(ogen) amyloid microclots and platelet hyperactivation previously reported as a novel finding in South African patients with the coronavirus 2019 disease (COVID-19) and Long COVID/Post-Acute Sequelae of COVID-19 (PASC), might form a suitable set of foci for the clinical treatment of the symptoms of Long COVID/PASC. A Long COVID/PASC Registry was subsequently established as an online platform where patients can report Long COVID/PASC symptoms and previous comorbidities. METHODS: In this study, we report on the comorbidities and persistent symptoms, using data obtained from 845 South African Long COVID/PASC patients. By using a previously published scoring system for fibrin a

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  13. A Scoping Review on Long COVID-19: Physiological and Psychological Symptoms Post-Acute, Long-Post and Persistent Post COVID-19

    Krishna Mohan Surapaneni, Manmohan Singhal, Sofia Rani Saggu, et al. · 2022 · Healthcare · 15 citations

    Background: The identification of persistent symptoms of chronic/long COVID-19 is crucial in understanding the management of long haulers of post COVID-19. Methods: Pub Med (Medline) database was scoped for original articles based on a search strategy related to the objectives. The selected articles post-screening were analyzed for variables relating to chronic/long COVID-19. Results were analyzed using descriptive statistics. Results: A total of 33 studies were reviewed. A total of 60% of the studies were observational studies and most of them were from high income countries. Almost half of the studies were in phase 3 of post-COVID-19, i.e., symptoms lasting >24 weeks. Among the physiolo

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  14. Potential of Black Seeds (Nigella sativa) in the Management of Long COVID or Post-acute Sequelae of COVID-19 (PASC) and Persistent COVID-19 Symptoms – An Insight

    Naina Mohamed Pakkir Maideen, Abdurazak Hassan Jumale, Ibrahim Ramadan Barakat, et al. · 2023 · Infectious Disorders - Drug Targets · 7 citations

    Background: Some individuals may experience symptoms persisting for many months after the recovery from COVID-19 and patients with Long COVID are managed mainly with symptomatic treatment and supportive care. Objective: This review article focuses on the beneficial effects of black seeds (Nigella Sativa) in the management of long COVID and persistent COVID symptoms. Methods: The literature was searched in databases such as LitCOVID, Web of Science, Google Scholar, bioRxiv, medRxiv, Science Direct, EBSCO, Scopus, Embase, and reference lists to identify studies, which evaluated various effects of black seeds (N. sativa) related to signs and symptoms of Long COVID. Results: Black seeds (

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  18. Post-Acute-COVID-19-Illness Neuropsychiatric Sequelae

    Attapon Cheepsattayakorn · 2021 · Open Access Journal of Pulmonary & Respiratory Sciences

    Direct viral invasion, neurodegeneration, microvascular thrombosis, neuroinflammation, and severe systemic inflammation can be the causes of post-acute-COVID-19- illness neuropathology [1-4], supported by brain parenchyma and vessel changes of possibly driven inflammation in neurons, supportive cells, and brain vasculature in COVID-19 autopsy series [5,6]. A role in persistent brain effects of SARSCoV-2 (COVID-19) may be played by an accumulation of memory T cells, a biomarker of immunosenescence in tissue injury and aging, accompanying with the decreased ability to respond to new antigens that are demonstrated in chronic low-level brain inflammation [7].

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  21. Effect of COVID Vaccine on Long COVID: An Observational Study on Hospitalised Patients in North India

    Sandeep Budhiraja, Abhaya Indrayan, Monica Mahajan · 2024 · Effect of COVID Vaccine on Long COVID: An Observational Study on Hospitalised Patients in North India

    We know that vaccination reduces the risk of hospitalisation and death but how these vaccines impact long-COVID is under debate. The current study analyses the patterns of long-COVID amongst vaccinated and unvaccinated hospitalised patients during the three waves in India. From the computerised medical records of COVID patients admitted to a group of hospitals in and around Delhi every 3rd case of wave-1 and wave-2 and all cases of wave-3 were telephonically contacted in April 2022 for symptoms and their duration of long-COVID and their vaccination status. Of the 6676 contacted, 6056 (90.7%) responded. These were compared for two groups: fully vaccinated (913) and unvaccinated at the time o

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  23. Age Differences in Becoming COVID Long-Haulers and in Post-Acute Sequelae of SARS-CoV-2

    Qiao Wu, Eileen Crimmins · 2021 · Innovation in Aging

    Abstract People who have had COVID-19 can suffer from the continuation of Post-Acute Sequelae of SARS-CoV-2 (PASC), also known as “long COVID”, for months after infection. Understanding PASC is important for treatment, care, and projecting future health of the population. Since older adults are at higher risk of severe illness and consequences from COVID, we hypothesize that they are more likely to become COVID long-haulers and report more symptoms at the time of diagnosis and three months after. We use a nationally representative sample of adults from the Understanding America Study COVID-19 Survey, from March to December 2020, to estimate the prevalence of long COVID and ide

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