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Research papers on Statins and heart disease

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  1. Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019

    Gregory A. Roth, George A. Mensah, Catherine O. Johnson, et al. · 2020 · Journal of the American College of Cardiology · 11,255 citations

    Cardiovascular diseases (CVDs), principally ischemic heart disease (IHD) and stroke, are the leading cause of global mortality and a major contributor to disability. This paper reviews the magnitude of total CVD burden, including 13 underlying causes of cardiovascular death and 9 related risk factors, using estimates from the Global Burden of Disease (GBD) Study 2019. GBD, an ongoing multinational collaboration to provide comparable and consistent estimates of population health over time, used all available population-level data sources on incidence, prevalence, case fatality, mortality, and health risks to produce estimates for 204 countries and territories from 1990 to 2019. Prevalent case

  2. European Guidelines on cardiovascular disease prevention in clinical practice (version 2012): The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts) * Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR)

    Authors/Task Force Members:, Joep Perk, Guy De Backer, et al. · 2012 · European Heart Journal · 8,522 citations

    C-reactive protein CURE Clopidogrel in Unstable Angina to Prevent Recurrent Events CVD cardiovascular disease DALYs disability-adjusted life years DBP diastolic blood

  4. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice

    Frank L.J. Visseren, François Mach, Yvo M. Smulders, et al. · 2021 · European Heart Journal · 6,370 citations

    The ESC Guidelines represent the views of the ESC and were produced after careful consideration of the scientific and medical knowledge and the evidence available at the time of their publication. The ESC is not responsible in the event of any contradiction, discrepancy and/or ambiguity between the ESC Guidelines and any other official recommendations or guidelines issued by the relevant public health authorities, in particular in relation to good use of healthcare or therapeutic strategies. Health professionals are encouraged to take the ESC Guidelines fully into account when exercising their clinical judgment, as well as in the determination and the implementation of preventive, diagnostic

  5. Statins for the primary prevention of cardiovascular disease

    Fiona Taylor, Mark D. Huffman, Ana Filipa Macedo, et al. · 2013 · Cochrane Database of Systematic Reviews · 1,836 citations

    BACKGROUND: Reducing high blood cholesterol, a risk factor for cardiovascular disease (CVD) events in people with and without a past history of CVD is an important goal of pharmacotherapy. Statins are the first-choice agents. Previous reviews of the effects of statins have highlighted their benefits in people with CVD. The case for primary prevention was uncertain when the last version of this review was published (2011) and in light of new data an update of this review is required. OBJECTIVES: To assess the effects, both harms and benefits, of statins in people with no history of CVD. SEARCH METHODS: To avoid duplication of effort, we checked reference lists of previous systematic reviews.

  6. Statin Use for the Primary Prevention of Cardiovascular Disease in Adults

    US Preventive Services Task Force, Kirsten Bibbins‐Domingo, David C. Grossman, et al. · 2016 · JAMA · 585 citations

    Importance: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the United States, accounting for 1 of every 3 deaths among adults. Objective: To update the 2008 US Preventive Services Task Force (USPSTF) recommendation on screening for lipid disorders in adults. Evidence Review: The USPSTF reviewed the evidence on the benefits and harms of screening for and treatment of dyslipidemia in adults 21 years and older; the benefits and harms of statin use in reducing CVD events and mortality in adults without a history of CVD events; whether the benefits of statin use vary by subgroup, clinical characteristics, or dosage; and the benefits of various treatment strategies

  7. Statins for Prevention of Cardiovascular Disease in Adults

    Roger Chou, Tracy Dana, Ian Blazina, et al. · 2016 · JAMA · 564 citations

    Importance: Cardiovascular disease (CVD), the leading cause of mortality and morbidity in the United States, may be potentially preventable with statin therapy. Objective: To systematically review benefits and harms of statins for prevention of CVD to inform the US Preventive Services Task Force. Data Sources: Ovid MEDLINE (from 1946), Cochrane Central Register of Controlled Trials (from 1991), and Cochrane Database of Systematic Reviews (from 2005) to June 2016. Study Selection: Randomized clinical trials of statins vs placebo, fixed-dose vs titrated statins, and higher- vs lower-intensity statins in adults without prior cardiovascular events. Data Extraction and Synthesis: One investigator

  9. Primary Prevention of Cardiovascular Diseases With Statin Therapy

    Paaladinesh Thavendiranathan · 2006 · Archives of Internal Medicine · 353 citations

    BACKGROUND: While the role of hydroxymethyl glutaryl coenzyme A reductase inhibitors (statins) in secondary prevention of cardiovascular (CV) events and mortality is established, their value for primary prevention is less clear. To clarify the role of statins for patients without CV disease, we performed a meta-analysis of randomized controlled trials (RCTs). METHODS: MEDLINE, EMBASE, Cochrane Collaboration, and American College of Physicians Journal Club databases were searched for RCTs published between 1966 and June 2005. We included RCTs with follow-up of 1 year or longer, more than 100 major CV events, and 80% or more of the population without CV disease. From each trial, demographic da

  11. Statins for the Prevention of Cardiovascular Disease

    Jill Jin · 2022 · JAMA · 3 citations

    This JAMA Patient Page summarizes the US Preventive Services Task Force’s recent recommendations on using statins for primary prevention of cardiovascular disease in adults.

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