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Research papers on Intermittent fasting and metabolism

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  1. Diagnosis and Management of the Metabolic Syndrome

    Scott M. Grundy, James I. Cleeman, Stephen R. Daniels, et al. · 2005 · Circulation · 11,891 citations

    The metabolic syndrome has received increased attention in the past few years. This statement from the American Heart Association (AHA) and the National Heart, Lung, and Blood Institute (NHLBI) is intended to provide up-to-date guidance for professionals on the diagnosis and management of the metabolic syndrome in adults. The metabolic syndrome is a constellation of interrelated risk factors of metabolic origin— metabolic risk factors —that appear to directly promote the development of atherosclerotic cardiovascular disease (ASCVD).1 Patients with the metabolic syndrome also are at increased risk for developing type 2 diabetes mellitus. Another set of conditions, the underlying risk factors

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  2. Physical Activity and Public Health

    William L. Haskell, I‐Min Lee, Russell R. Pate, et al. · 2007 · Circulation · 6,569 citations

    SUMMARY: In 1995 the American College of Sports Medicine and the Centers for Disease Control and Prevention published national guidelines on Physical Activity and Public Health. The Committee on Exercise and Cardiac Rehabilitation of the American Heart Association endorsed and supported these recommendations. The purpose of the present report is to update and clarify the 1995 recommendations on the types and amounts of physical activity needed by healthy adults to improve and maintain health. Development of this document was by an expert panel of scientists, including physicians, epidemiologists, exercise scientists, and public health specialists. This panel reviewed advances in pertinent ph

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  6. Metabolic Effects of Intermittent Fasting

    Ruth E. Patterson, Dorothy D. Sears · 2017 · Annual Review of Nutrition · 820 citations

    The objective of this review is to provide an overview of intermittent fasting regimens, summarize the evidence on the health benefits of intermittent fasting, and discuss physiological mechanisms by which intermittent fasting might lead to improved health outcomes. A MEDLINE search was performed using PubMed and the terms "intermittent fasting," "fasting," "time-restricted feeding," and "food timing." Modified fasting regimens appear to promote weight loss and may improve metabolic health. Several lines of evidence also support the hypothesis that eating patterns that reduce or eliminate nighttime eating and prolong nightly fasting intervals may result in sustained improvements in human hea

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  7. Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting

    Stephen D. Anton, Keelin Moehl, William T. Donahoo, et al. · 2017 · Obesity · 774 citations

    OBJECTIVE: Intermittent fasting (IF) is a term used to describe a variety of eating patterns in which no or few calories are consumed for time periods that can range from 12 hours to several days, on a recurring basis. This review is focused on the physiological responses of major organ systems, including the musculoskeletal system, to the onset of the metabolic switch: the point of negative energy balance at which liver glycogen stores are depleted and fatty acids are mobilized (typically beyond 12 hours after cessation of food intake). RESULTS AND CONCLUSIONS: Emerging findings suggest that the metabolic switch from glucose to fatty acid-derived ketones represents an evolutionarily conserv

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  9. Intermittent Fasting and Metabolic Health

    Izzah Vasim, Chaudry Nasir Majeed, Mark D. DeBoer · 2022 · Nutrients · 284 citations

    Given the ongoing strain that the obesity epidemic has placed on public health outcomes, new and effective approaches to weight control are needed. One approach to improving weight and metabolic outcomes is intermittent fasting, which consists of multiple different timing schedules for temporary food avoidance, including alternate-day fasting, other similar full-day fasting patterns, and time-restricted feeding (where the day's food is consumed over a 6-h period, allowing for 18 h of fasting). These feeding schedules have favorable metabolic effects by intermittently inducing the metabolism of fatty acids to ketones. The regimens overall lead to a decrease in weight and have been linked to i

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  10. Cardiometabolic Benefits of Intermittent Fasting

    Krista A Varady, Sofia Cienfuegos, Mark Ezpeleta, et al. · 2021 · Annual Review of Nutrition · 187 citations

    This review aims to summarize the effects of intermittent fasting on markers of cardiometabolic health in humans. All forms of fasting reviewed here-alternate-day fasting (ADF), the 5:2 diet, and time-restricted eating (TRE)-produced mild to moderate weight loss (1-8% from baseline) and consistent reductions in energy intake (10-30% from baseline). These regimens may benefit cardiometabolic health by decreasing blood pressure, insulin resistance, and oxidative stress. Low-density lipoprotein cholesterol and triglyceride levels are also lowered, but findings are variable. Other health benefits, such as improved appetite regulation and favorable changes in the diversity of the gut microbiome,

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  11. The role of intermittent fasting and meal timing in weight management and metabolic health

    Iain Templeman, Javier T. Gonzalez, Dylan Thompson, et al. · 2019 · Proceedings of The Nutrition Society · 85 citations

    Obesity remains a major public health concern and intermittent fasting is a popular strategy for weight loss, which may present independent health benefits. However, the number of diet books advising how fasting can be incorporated into our daily lives is several orders of magnitude greater than the number of trials examining whether fasting should be encouraged at all. This review will consider the state of current understanding regarding various forms of intermittent fasting (e.g. 5:2, time-restricted feeding and alternate-day fasting). The efficacy of these temporally defined approaches appears broadly equivalent to that of standard daily energy restriction, although many of these models

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  12. Effects of Intermittent Fasting on Weight Loss and Cardiometabolic Health

    Rümeysa GERBOĞA, Cansu BEKAR · 2023 · Current Perspectives on Health Sciences · 2 citations

    Intermittent fasting is a cyclical way of eating that is formed by the succession of eating and fasting period. It includes a long period of fasting, such as 16-48 hours, in which individuals receive little or no energy, and a normal eating period. The most commonly applied methods are alternate day fasting (ADF), time-restricted feeding (TRF) the 5:2 diet and Ramadan fasting. It has been reported that these diet models can be an alternative to continuous energy restriction in the medical nutrition treatment of obesity and are effective in weight loss. Intermittent fasting can have positive effects on reducing the risk of cardiovascular diseases and improving symptoms by causing reductions i

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  14. Intermittent Fasting: Effects on Weight Loss, Metabolic Health, and Cognitive Function – A Systematic Review

    İpek Türkmen · 2024 · Next Generation Journal for The Young Researchers

    Intermittent fasting (IF) has gained widespread attention as a dietary strategy for weight loss and improving overall health. This systematic review aims to evaluate the effects of intermittent fasting on weight loss, metabolic health, and cognitive function by analyzing data from various clinical trials and studies. The review compares different intermittent fasting protocols, such as time-restricted eating, alternate-day fasting, and the 5:2 diet, and examines their impact on body weight, fat loss, insulin sensitivity, cholesterol levels, and inflammation markers. Additionally, the review explores the potential cognitive benefits of intermittent fasting, focusing on improvements in memory

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  15. Unlocking Health: The Rise of Intermittent Fasting for Weight Loss and Metabolic Wellness

    Dr. Somenath Ghosh, Dr. John Abraham, E. Lakshmi · 2024 · International Journal of Pharma and Bio Sciences

    Intermittent fasting (IF), encompassing methods like alternate-day fasting (ADF), the 5:2 diet, and time-restricted feeding (TRF), has garnered significant attention for its potential health benefits. TRF involves consuming food within an 8-hour daily window, leading to metabolic shifts and adaptive responses in the brain and nervous system. IF often results in reduced calorie intake, similar to calorie restriction (CR) regimens in laboratory studies. IF also promotes autophagy, reducing inflammation and oxidative stress and lowering the health risk of chronic diseases like cancer and neurodegenerative disorders. IF may enhance sleep quality and duration by aligning eating patterns with circ

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  16. Impact of Intermittent Fasting on Human Endocrine and Metabolic Physiology: A Systematic Review

    Syed Soban Ahmed Tirimzi, Maham Khalid, Ambar Shuaib, et al. · 2026 · Pakistan Journal of Health Sciences

    Intermittent fasting (IF) is increasingly recognized as a dietary approach that may improve endocrine and cardiometabolic health by aligning eating patterns with circadian rhythms. Objectives: To systematically evaluate recent human studies (2018–2024) investigating the effects of intermittent fasting on endocrine and metabolic physiology, with emphasis on insulin sensitivity, hormonal balance, and cardiometabolic outcomes. Methods: PubMed, Scopus, and the Cochrane Library were searched according to PRISMA 2020 guidelines. Randomized controlled, crossover, cohort, and observational studies reporting endocrine (insulin, leptin, ghrelin, cortisol) and metabolic (glucose, lipids, body compositi

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  17. The Impact of Intermittent Fasting on Metabolic Health and Chronic Disease Prevention: A Comprehensive Review

    Arisa Tantirasmee · 2024 · International Journal of Current Science Research and Review

    Intermittent fasting has gained attention as a dietary approach focusing on the timing of eating rather than the specific foods being consumed. Unlike the traditional calorie restriction, intermittent fasting involves alternating periods of fasting and eating. Several prevalent forms of IF exist, each with unique fasting durations and eating windows. For instance, the 16/8 method restricts food intake to an 8-hour window each day, followed by 16 hours of fasting. The 5:2 diet involves eating regular meals for five days a week and significantly reducing calorie intake to 500-600 calories on the remaining two non-consecutive days. Another popular method, Eat-Stop-Eat, includes one or two 24-ho

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  19. INTERMITTENT FASTING AND CHRONONUTRITION: SYNERGISTIC APPROACHES FOR METABOLIC HEALTH

    Andressa dos Reis Gonçalves Mariani · 2023 · Revista Sistemática

    Intermittent fasting (IF) and chrononutrition are emerging dietary strategies that align eating patterns with human circadian rhythms to improve metabolic health. While intermittent fasting emphasizes extended periods without caloric intake, chrononutrition focuses on the timing of food consumption relative to biological clocks. Both approaches have been associated with improvements in insulin sensitivity, lipid metabolism, and weight management. Evidence suggests that meal timing plays a critical role in regulating circadian physiology, influencing hormone secretion, glucose metabolism, and energy expenditure. Integrating principles of IF and chrononutrition may provide synergistic benefits

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  20. Effects of Intermittent Fasting on Weight Loss and Metabolic Health

    Anna Kaźmierczak, Klaudia Perkowska, Anna Kiełb, et al. · 2024 · Quality in Sport

    Introduction and Purpose: Intermittent fasting (IF) has become a popular strategy for combating obesity and improving metabolic health. This dietary regimen alternates between periods of fasting and eating, aiming to enhance cellular health and increase longevity. With obesity rates doubling globally since 1990 and metabolic diseases on the rise, IF offers a potential solution by promoting metabolic benefits and reducing obesity-related conditions. Material and Method: This review examines various IF methods, including alternate-day fasting, the 5:2 diet, and time-restricted eating. The analysis focuses on the impact of these fasting methods on body weight, insulin sensitivity, and lipid pr

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