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Research papers on Intermittent fasting and metabolism

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  1. Diagnosis and Management of the Metabolic Syndrome

    Scott M. Grundy, James I. Cleeman, Stephen R. Daniels, et al. · 2005 · Circulation · 11,834 citations

    The metabolic syndrome has received increased attention in the past few years. This statement from the American Heart Association (AHA) and the National Heart, Lung, and Blood Institute (NHLBI) is intended to provide up-to-date guidance for professionals on the diagnosis and management of the metabolic syndrome in adults. The metabolic syndrome is a constellation of interrelated risk factors of metabolic origin— metabolic risk factors —that appear to directly promote the development of atherosclerotic cardiovascular disease (ASCVD).1 Patients with the metabolic syndrome also are at increased risk for developing type 2 diabetes mellitus. Another set of conditions, the underlying risk factors

  2. Physical Activity and Public Health

    William L. Haskell, I‐Min Lee, Russell R. Pate, et al. · 2007 · Circulation · 6,553 citations

    SUMMARY: In 1995 the American College of Sports Medicine and the Centers for Disease Control and Prevention published national guidelines on Physical Activity and Public Health. The Committee on Exercise and Cardiac Rehabilitation of the American Heart Association endorsed and supported these recommendations. The purpose of the present report is to update and clarify the 1995 recommendations on the types and amounts of physical activity needed by healthy adults to improve and maintain health. Development of this document was by an expert panel of scientists, including physicians, epidemiologists, exercise scientists, and public health specialists. This panel reviewed advances in pertinent ph

  6. Metabolic Effects of Intermittent Fasting

    Ruth E. Patterson, Dorothy D. Sears · 2017 · Annual Review of Nutrition · 810 citations

    The objective of this review is to provide an overview of intermittent fasting regimens, summarize the evidence on the health benefits of intermittent fasting, and discuss physiological mechanisms by which intermittent fasting might lead to improved health outcomes. A MEDLINE search was performed using PubMed and the terms "intermittent fasting," "fasting," "time-restricted feeding," and "food timing." Modified fasting regimens appear to promote weight loss and may improve metabolic health. Several lines of evidence also support the hypothesis that eating patterns that reduce or eliminate nighttime eating and prolong nightly fasting intervals may result in sustained improvements in human hea

  7. Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting

    Stephen D. Anton, Keelin Moehl, William T. Donahoo, et al. · 2017 · Obesity · 761 citations

    OBJECTIVE: Intermittent fasting (IF) is a term used to describe a variety of eating patterns in which no or few calories are consumed for time periods that can range from 12 hours to several days, on a recurring basis. This review is focused on the physiological responses of major organ systems, including the musculoskeletal system, to the onset of the metabolic switch: the point of negative energy balance at which liver glycogen stores are depleted and fatty acids are mobilized (typically beyond 12 hours after cessation of food intake). RESULTS AND CONCLUSIONS: Emerging findings suggest that the metabolic switch from glucose to fatty acid-derived ketones represents an evolutionarily conserv

  8. [Intermittent fasting and human metabolic health].

    V. Carvajal, A. Marín, Daniela Gihardo, et al. · 2023 · Revista medica de Chile · 395 citations

    Intermittent fasting (IF) has gained increasing scientific and general attention. Most studied forms of IF include alternate-day fasting, modified alternate-day fasting, and time-restricted eating (TRE). Several cardiometabolic effects of IF have been described in animal models and, to a lesser extent, in humans. This review analyzes the impact of IF on weight loss, glucose metabolism, blood pressure, and lipid profile in humans. A literature search was conducted in the Pubmed/Medline, Scopus, and Google Scholar databases. Controlled observational or interventional studies in humans, published between January 2000 and June 2021, were included. Studies comparing IF versus religious fasting we

  9. Intermittent Fasting and Metabolic Health

    I. Vasim, C. Majeed, M. DeBoer · 2022 · Nutrients · 274 citations

    Given the ongoing strain that the obesity epidemic has placed on public health outcomes, new and effective approaches to weight control are needed. One approach to improving weight and metabolic outcomes is intermittent fasting, which consists of multiple different timing schedules for temporary food avoidance, including alternate-day fasting, other similar full-day fasting patterns, and time-restricted feeding (where the day’s food is consumed over a 6-h period, allowing for 18 h of fasting). These feeding schedules have favorable metabolic effects by intermittently inducing the metabolism of fatty acids to ketones. The regimens overall lead to a decrease in weight and have been linked to i

  10. Cardiometabolic Benefits of Intermittent Fasting

    Krista A Varady, Sofia Cienfuegos, Mark Ezpeleta, et al. · 2021 · Annual Review of Nutrition · 179 citations

    This review aims to summarize the effects of intermittent fasting on markers of cardiometabolic health in humans. All forms of fasting reviewed here-alternate-day fasting (ADF), the 5:2 diet, and time-restricted eating (TRE)-produced mild to moderate weight loss (1-8% from baseline) and consistent reductions in energy intake (10-30% from baseline). These regimens may benefit cardiometabolic health by decreasing blood pressure, insulin resistance, and oxidative stress. Low-density lipoprotein cholesterol and triglyceride levels are also lowered, but findings are variable. Other health benefits, such as improved appetite regulation and favorable changes in the diversity of the gut microbiome,

  11. The role of intermittent fasting and meal timing in weight management and metabolic health

    Iain Templeman, Javier T. Gonzalez, Dylan Thompson, et al. · 2019 · Proceedings of the Nutrition Society · 83 citations

    Obesity remains a major public health concern and intermittent fasting is a popular strategy for weight loss, which may present independent health benefits. However, the number of diet books advising how fasting can be incorporated into our daily lives is several orders of magnitude greater than the number of trials examining whether fasting should be encouraged at all. This review will consider the state of current understanding regarding various forms of intermittent fasting (e.g. 5:2, time-restricted feeding and alternate-day fasting). The efficacy of these temporally defined approaches appears broadly equivalent to that of standard daily energy restriction, although many of these models

  12. Intermittent Fasting Regulates Metabolic Homeostasis and Improves Cardiovascular Health

    Rawan Diab, Lina Dimachkie, Omar Zein, et al. · 2024 · Cell Biochemistry and Biophysics · 24 citations

    Obesity is a leading cause of morbidity and mortality globally. While the prevalence of obesity has been increasing, the incidence of its related complications including dyslipidemia and cardiovascular disease (CVD) has also been rising. Recent research has focused on modalities aimed at reducing obesity. Several modalities have been suggested including behavioral and dietary changes, medications, and bariatric surgery. These modalities differ in their effectiveness and invasiveness, with dietary changes gaining more interest due to their minimal risks compared to other modalities. Specifically, intermittent fasting (IF) has been gaining interest in the past decade. IF is characterized by cy

  13. Intermittent fasting, exercise and dietary modification induce unique transcriptomic signatures of multiple tissues governing metabolic homeostasis during weight loss and rebound weight gain.

    Tianqi Liu, Yuan Liu, Tao Yan, et al. · 2024 · The Journal of nutritional biochemistry · 13 citations

    Obesity and its related metabolic diseases bring great challenges to public health. In-depth understanding on the efficacy of weight-loss interventions is critical for long-term weight control. Our study demonstrated the comparable efficacy of exercise (EX), intermittent fasting (IF), or the change of daily diet from an unhealthy to a normal chow (DR) for weight reduction, but largely divergently affected metabolic status and transcriptome of subcutaneous fat, scapular brown fat, skeletal muscles and liver in high-fat-high-fructose diet (HFHF) induced obese mice. EX and IF reduced systematic inflammation, improved glucose and lipid metabolism in liver and muscle, and amino acid metabolism an

  15. Assessing the impact of intermittent fasting and a low-carbohydrate-high-protein diet on metabolic health and pancreatic histopathology in type 2 diabetic rat model

    Arwa M. Alqusayer, W. Ahmed, S. Althwab, et al. · 2025 · International Journal of Health Sciences · 2 citations

    ABSTRACT Objective: The current study was conducted to investigate the effect of intermittent fasting (IF) with a low-carbohydrate-high-protein (LCHP) diet on blood glucose control in streptozotocin (STZ)-nicotinamide-induced type 2 diabetic rats (DR). Methods: Thirty male Wistar rats were divided into six groups (n = 5) including a group of normal rats (NR) that received a control diet (CD) (50% carbohydrates, 17% protein, and 33% fat) with ad libitum (AL) feeding. The remaining 5 groups were DR injected with STZ and fed on CD or LCHP diet (40% carbohydrates, 30% protein, and 30% fat) for 6 weeks, either AL or IF (with a time-restricted feeding of 16 h followed by 8 h feeding period). There

  16. Effects of Intermittent Fasting on Weight Loss and Cardiometabolic Health

    Rümeysa GERBOĞA, Cansu BEKAR · 2023 · Current Perspectives on Health Sciences · 2 citations

    Intermittent fasting is a cyclical way of eating that is formed by the succession of eating and fasting period. It includes a long period of fasting, such as 16-48 hours, in which individuals receive little or no energy, and a normal eating period. The most commonly applied methods are alternate day fasting (ADF), time-restricted feeding (TRF) the 5:2 diet and Ramadan fasting. It has been reported that these diet models can be an alternative to continuous energy restriction in the medical nutrition treatment of obesity and are effective in weight loss. Intermittent fasting can have positive effects on reducing the risk of cardiovascular diseases and improving symptoms by causing reductions i

  17. Sports Performance and Intermittent Fasting: Impact on Training and Results, Mechanisms and Health Benefits in Weight Management, Metabolic Health, and Chronic Diseases – A Review of Risks, Current Evidence, and Future Research Directions

    Mateusz Bieńko, Marta Rutkowska, Tomasz Król, et al. · 2024 · Quality in Sport · 1 citations

    Introduction: Intermittent Fasting (IF) has become a popular method in the contemporary medical world as an up-to date technique of the health and wellbeing in the last several years. Purpose: This research aims to investigate the both impact of IF on sports performance and therapeutic potential of IF on cardiovascular, metabolic and neurological diseases with focus on obesity, diabetes and impact on cardiometabolic risk. State of Knowledge: Intermittent fasting has been found to extend both life and health span by positively impacting weight management, reducing the risk of cardiovascular incidents, promoting cellular repair, and exhibiting anti-inflammatory actions. It improves blood

  18. The impact of Intermittent Fasting on Weight Loss and Metabolic Health - a review of the latest research

    M. J. Gonciarz, Dominika Karolina Adamiec, Anna Dąbrowska, et al. · 2024 · Quality in Sport · 1 citations

    Introduction and purpose        Intermittent fasting (IF) is a dietary pattern that alternates between periods of fasting or reduced caloric intake and periods of unrestricted eating. There are three primary types of IF: Alternate Day Fasting (ADF), Time-Restricted Eating (TRE), and Periodic Fasting (PF). This review article summarizes the impact of IF on weight loss. Additionally, it examines the broader health effects of IF, including its influence on cardiovascular risk, diabetes management, and neurodegenerative diseases.    Description of the state of knowledge        Fasting, the practice of abstaining from or limiting food intake for a specified period, has been a cultural and religio

  19. “Intermittent Fasting and Type 2 Diabetes: Impacts on Glycemic Control and Metabolic Health

    Tvisa Punyatoya, Bhavana S · 2025 · International Journal For Multidisciplinary Research · 1 citations

    Type 2 Diabetes Mellitus (T2DM) remains a growing global health challenge, driven by increasing obesity, poor dietary patterns, and sedentary lifestyles. In recent years, intermittent fasting (IF) has emerged as a promising non-pharmacological intervention for improving glycemic control and metabolic outcomes in T2DM patients. This review explores the mechanisms linking IF to enhanced insulin sensitivity, reduced oxidative stress, circadian regulation, and metabolic flexibility. Clinical trials and meta-analyses have demonstrated significant improvements in HbA1c, fasting glucose, weight loss, and insulin resistance with various IF regimens such as time restricted eating (TRE), alternate-da

  20. Long-term Effects of Intermittent Fasting on Weight Loss and Metabolic Risk Factors: A Systematic Review of Randomized Controlled Trials

    Eleni Vlastaridou, Sofia Blatsiou, Ioanna Kosma, et al. · 2025 · Journal of Atherosclerosis Prevention and Treatment · 1 citations

    Obesity is rising globally, posing public health challenges and highlighting the need for effective, evidence-based dietary interventions. Intermittent fasting (IF), involving alternating periods of eating and fasting, is a promising alternative to continuous energy restriction (CER) for metabolic health. This systematic review evaluated the long-term effects (≥12 months) of IF compared with control diets on body weight and markers of metabolic health in adults with overweight or obesity. MEDLINE/PubMed and Scopus were systematically searched through July 2025 following Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines, and study quality was assessed using the C

  21. Intermittent Fasting: Effects on Weight Loss, Metabolic Health, and Cognitive Function – A Systematic Review

    İpek Türkmen · 2024 · Next Generation Journal for The Young Researchers

    Intermittent fasting (IF) has gained widespread attention as a dietary strategy for weight loss and improving overall health. This systematic review aims to evaluate the effects of intermittent fasting on weight loss, metabolic health, and cognitive function by analyzing data from various clinical trials and studies. The review compares different intermittent fasting protocols, such as time-restricted eating, alternate-day fasting, and the 5:2 diet, and examines their impact on body weight, fat loss, insulin sensitivity, cholesterol levels, and inflammation markers. Additionally, the review explores the potential cognitive benefits of intermittent fasting, focusing on improvements in memory

  22. Effects of Intermittent Fasting on Weight Loss and Metabolic Health

    Anna Kaźmierczak, Klaudia Perkowska, Anna Kiełb, et al. · 2024 · Quality in Sport

    Introduction and Purpose: Intermittent fasting (IF) has become a popular strategy for combating obesity and improving metabolic health. This dietary regimen alternates between periods of fasting and eating, aiming to enhance cellular health and increase longevity. With obesity rates doubling globally since 1990 and metabolic diseases on the rise, IF offers a potential solution by promoting metabolic benefits and reducing obesity-related conditions. Material and Method: This review examines various IF methods, including alternate-day fasting, the 5:2 diet, and time-restricted eating. The analysis focuses on the impact of these fasting methods on body weight, insulin sensitivity, and lipid pr

  23. ROLE OF INTERMITTENT FASTING ON METABOLIC HEALTH IN OVERWEIGHT ADULTS A NARRATIVE REVIEW

    Akif Saeed Ch, Naheed Shah, Shaikh Khalid Muhammad, et al. · 2025 · Insights-Journal of Health and Rehabilitation

    Background: Intermittent fasting (IF) has emerged as a widely practiced dietary strategy with growing scientific interest for its potential role in managing obesity and improving metabolic health. With global rates of overweight and obesity rising at an alarming pace, effective non-pharmacologic interventions are increasingly needed to address associated metabolic disorders such as insulin resistance, dyslipidemia, and impaired glucose regulation. Objective: This narrative review aims to explore the metabolic effects of intermittent fasting in overweight and obese adults, highlighting its clinical benefits, potential limitations, and areas requiring further investigation. Main Discussion Poi

  24. Unlocking Health: The Rise of Intermittent Fasting for Weight Loss and Metabolic Wellness

    Dr. Somenath Ghosh, D. Abraham, E. Lakshmi · 2024 · International Journal of Pharma and Bio Sciences

    Intermittent fasting (IF), encompassing methods like alternate-day fasting (ADF), the 5:2 diet, and time-restricted feeding (TRF), has garnered significant attention for its potential health benefits. TRF involves consuming food within an 8-hour daily window, leading to metabolic shifts and adaptive responses in the brain and nervous system. IF often results in reduced calorie intake, similar to calorie restriction (CR) regimens in laboratory studies. IF also promotes autophagy, reducing inflammation and oxidative stress and lowering the health risk of chronic diseases like cancer and neurodegenerative disorders. IF may enhance sleep quality and duration by aligning eating patterns with circ

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