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Papers on “antibiotic resistance antimicrobial mechanisms”

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  1. Antibiotic development challenges: the various mechanisms of action of antimicrobial peptides and of bacterial resistance

    Fernanda Guilhelmelli, Nathália Vilela, Patrícia Albuquerque, et al. · 2013 · Frontiers in Microbiology · 548 cites

    Antimicrobial peptides (AMPs) are natural antibiotics produced by various organisms such as mammals, arthropods, plants, and bacteria. In addition to antimicrobial activity, AMPs can induce chemokine production, accelerate angiogenesis, and wound healing and modulate apoptosis in multicellular organisms. Originally, their antimicrobial mechanism of action was thought to consist solely of an increase in pathogen cell membrane permeability, but it has already been shown that several AMPs do not modulate membrane permeability in the minimal lethal concentration. Instead, they exert their effects by inhibiting processes such as protein and cell wall synthesis, as well as enzyme activity, among o

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  2. Occurrence of antibiotics and bacterial resistance genes in wastewater: resistance mechanisms and antimicrobial resistance control approaches

    Mutuku S. Christopher, Zoltán Gazdag, Szilvia Melegh · 2022 · World Journal of Microbiology and Biotechnology · 280 cites

    Antimicrobial pharmaceuticals are classified as emergent micropollutants of concern, implying that even at low concentrations, long-term exposure to the environment can have significant eco-toxicological effects. There is a lack of a standardized regulatory framework governing the permissible antibiotic content for monitoring environmental water quality standards. Therefore, indiscriminate discharge of antimicrobials at potentially active concentrations into urban wastewater treatment facilities is rampant. Antimicrobials may exert selective pressure on bacteria, leading to resistance development and eventual health consequences. The emergence of clinically important multiple antibiotic-resi

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  3. Antibiotic resistance in the absence of antimicrobial use: mechanisms and implications

    Lucia Pallecchi, Alessandro Bartoloni, Franco Paradisi, et al. · 2008 · Expert Review of Anti-infective Therapy · 113 cites

    The selective pressure generated by the use of antibiotics in clinical, veterinary, husbandry and agricultural practices is considered the major factor responsible for the emergence and spread of antibiotic-resistant bacteria since the beginning of the antibiotic era. However, recent studies have consistently demonstrated that acquired resistance traits can also be found in bacteria isolated from humans and wild animals not subjected to significant antibiotic exposure and living in remote areas of the planet. The scope of this article is to review and discuss the current knowledge on this intriguing phenomenon, which underscores the complexity of the mechanisms involved in the emergence and

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  6. Antimicrobial Feature of Nanoparticles in the Antibiotic Resistance Era: From Mechanism to Application

    Hamed Salmani-Zarchi, Seyyed Mohammad Amin Mousavi-Sagharchi, Nafise Sepahdoost, et al. · 2024 · Advanced Biomedical Research · 43 cites

    The growth of nanoscale sciences enables us to define and design new methods and materials for a better life. Health and disease prevention are the main issues in the human lifespan. Some nanoparticles (NPs) have antimicrobial properties that make them useful in many applications. In recent years, NPs have been used as antibiotics to overcome drug resistance or as drug carriers with antimicrobial features. They can also serve as antimicrobial coatings for implants in different body areas. The antimicrobial feature of NPs is based on different mechanisms. For example, the oxidative functions of NPs can inhibit nucleic acid replication and destroy the microbial cell membrane as well as interfe

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