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Papers on “microbiome immune system regulation”

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1. Richness of human gut microbiome correlates with metabolic markers

   Emmanuelle Le Chatelier, Trine Skov Nielsen, Junjie Qin, et al. · 2013 · Nature · 4,840 cites

2. Interaction between microbiota and immunity in health and disease

   Danping Zheng, Timur Liwinski, Eran Elinav · 2020 · Cell Research · 4,032 cites

   The interplay between the commensal microbiota and the mammalian immune system development and function includes multifold interactions in homeostasis and disease. The microbiome plays critical roles in the training and development of major components of the host's innate and adaptive immune system, while the immune system orchestrates the maintenance of key features of host-microbe symbiosis. In a genetically susceptible host, imbalances in microbiota-immunity interactions under defined environmental contexts are believed to contribute to the pathogenesis of a multitude of immune-mediated disorders. Here, we review features of microbiome-immunity crosstalk and their roles in health and dise

3. Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases

   Daniela Parada Venegas, Marjorie K. De la Fuente, Glauben Landskron, et al. · 2019 · Frontiers in Immunology · 3,862 cites

   Ulcerative colitis (UC) and Crohn's disease (CD), collectively known as Inflammatory Bowel Diseases (IBD), are caused by a complex interplay between genetic, immunologic, microbial and environmental factors. Dysbiosis of the gut microbiome is increasingly considered to be causatively related to IBD and is strongly affected by components of a Western life style. Bacteria that ferment fibers and produce short chain fatty acids (SCFAs) are typically reduced in mucosa and feces of patients with IBD, as compared to healthy individuals. SCFAs, such as acetate, propionate and butyrate, are important metabolites in maintaining intestinal homeostasis. Several studies have indeed shown that fecal SCFA

4. Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment

   Xochitl C. Morgan, Timothy L. Tickle, Harry Sokol, et al. · 2012 · Genome biology · 2,818 cites

   BACKGROUND: The inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis result from alterations in intestinal microbes and the immune system. However, the precise dysfunctions of microbial metabolism in the gastrointestinal microbiome during IBD remain unclear. We analyzed the microbiota of intestinal biopsies and stool samples from 231 IBD and healthy subjects by 16S gene pyrosequencing and followed up a subset using shotgun metagenomics. Gene and pathway composition were assessed, based on 16S data from phylogenetically-related reference genomes, and associated using sparse multivariate linear modeling with medications, environmental factors, and IBD status. RESULTS: Firmi

5. The human skin microbiome

   Allyson L. Byrd, Yasmine Belkaid, Julia A. Segre · 2018 · Nature Reviews Microbiology · 2,813 cites

6. Gut microbiome and health: mechanistic insights

   Willem M. de Vos, Herbert Tilg, Matthias Van Hul, et al. · 2022 · Gut · 2,427 cites

   The gut microbiota is now considered as one of the key elements contributing to the regulation of host health. Virtually all our body sites are colonised by microbes suggesting different types of crosstalk with our organs. Because of the development of molecular tools and techniques (ie, metagenomic, metabolomic, lipidomic, metatranscriptomic), the complex interactions occurring between the host and the different microorganisms are progressively being deciphered. Nowadays, gut microbiota deviations are linked with many diseases including obesity, type 2 diabetes, hepatic steatosis, intestinal bowel diseases (IBDs) and several types of cancer. Thus, suggesting that various pathways involved i

7. The microbiome and innate immunity

   Christoph A. Thaiss, Niv Zmora, Maayan Levy, et al. · 2016 · Nature · 2,066 cites

8. Serotonin, tryptophan metabolism and the brain-gut-microbiome axis

   Siobhain M. O’Mahony, Gerard A. Clarke, Yuliya E. Borre, et al. · 2014 · Behavioural Brain Research · 2,056 cites