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Papers on “stem cell regenerative medicine therapy”

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1. Stem cells, cancer, and cancer stem cells

   Tannishtha Reya, Sean J. Morrison, Michael F. Clarke, et al. · 2001 · Nature · 9,791 cites

2. Adipose-Derived Stem Cells for Regenerative Medicine

   Jeffrey M. Gimble, Adam J. Katz, Bruce Alan Bunnell · 2007 · Circulation Research · 2,350 cites

   The emerging field of regenerative medicine will require a reliable source of stem cells in addition to biomaterial scaffolds and cytokine growth factors. Adipose tissue represents an abundant and accessible source of adult stem cells with the ability to differentiate along multiple lineage pathways. The isolation, characterization, and preclinical and clinical application of adipose-derived stem cells (ASCs) are reviewed in this article.

3. Adult mesenchymal stem cells for tissue engineering versus regenerative medicine

   Arnold I. Caplan · 2007 · Journal of Cellular Physiology · 1,967 cites

   Adult mesenchymal stem cells (MSCs) can be isolated from bone marrow or marrow aspirates and because they are culture-dish adherent, they can be expanded in culture while maintaining their multipotency. The MSCs have been used in preclinical models for tissue engineering of bone, cartilage, muscle, marrow stroma, tendon, fat, and other connective tissues. These tissue-engineered materials show considerable promise for use in rebuilding damaged or diseased mesenchymal tissues. Unanticipated is the realization that the MSCs secrete a large spectrum of bioactive molecules. These molecules are immunosuppressive, especially for T-cells and, thus, allogeneic MSCs can be considered for therapeutic

4. Induced pluripotent stem cell technology: a decade of progress

   Yanhong Shi, Haruhisa Inoue, Joseph C. Wu, et al. · 2016 · Nature Reviews Drug Discovery · 1,564 cites

5. Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic Strategies in Regenerative Medicine

   F. Vizoso, N. Eiro, Sandra Cid, et al. · 2017 · International Journal of Molecular Sciences · 1,208 cites

   Earlier research primarily attributed the effects of mesenchymal stem cell (MSC) therapies to their capacity for local engrafting and differentiating into multiple tissue types. However, recent studies have revealed that implanted cells do not survive for long, and that the benefits of MSC therapy could be due to the vast array of bioactive factors they produce, which play an important role in the regulation of key biologic processes. Secretome derivatives, such as conditioned media or exosomes, may present considerable advantages over cells for manufacturing, storage, handling, product shelf life and their potential as a ready-to-go biologic product. Nevertheless, regulatory requirements fo

6. Stem cell-based therapy for human diseases

   Duc Minh Hoang, Phuong T. Pham, Trung Q. Bach, et al. · 2022 · Signal Transduction and Targeted Therapy · 1,083 cites

   Recent advancements in stem cell technology open a new door for patients suffering from diseases and disorders that have yet to be treated. Stem cell-based therapy, including human pluripotent stem cells (hPSCs) and multipotent mesenchymal stem cells (MSCs), has recently emerged as a key player in regenerative medicine. hPSCs are defined as self-renewable cell types conferring the ability to differentiate into various cellular phenotypes of the human body, including three germ layers. MSCs are multipotent progenitor cells possessing self-renewal ability (limited in vitro) and differentiation potential into mesenchymal lineages, according to the International Society for Cell and Gene Therapy

7. Mesenchymal stem cell-derived extracellular vesicles: novel frontiers in regenerative medicine

   Somayeh Keshtkar, Negar Azarpira, Mohammad Hossein Ghahremani · 2018 · Stem Cell Research & Therapy · 937 cites

   Mesenchymal stem cells (MSCs) are multipotent stem cells that have gained significant attention in the field of regenerative medicine. The differentiation potential along with paracrine properties of MSCs have made them a key option for tissue repair. The paracrine functions of MSCs are applied through secreting soluble factors and releasing extracellular vesicles like exosomes and microvesicles. Extracellular vesicles are predominantly endosomal in origin and contain a cargo of miRNA, mRNA, and proteins that are transferred from their original cells to target cells. Recently it has emerged that extracellular vesicles alone are responsible for the therapeutic effect of MSCs in plenty of anim

8. Stem Cell Paracrine Actions and Tissue Regeneration

   Priya R. Baraniak, Todd C. McDevitt · 2009 · Regenerative Medicine · 865 cites

   Stem cells have emerged as a key element of regenerative medicine therapies due to their inherent ability to differentiate into a variety of cell phenotypes, thereby providing numerous potential cell therapies to treat an array of degenerative diseases and traumatic injuries. A recent paradigm shift has emerged suggesting that the beneficial effects of stem cells may not be restricted to cell restoration alone, but also due to their transient paracrine actions. Stem cells can secrete potent combinations of trophic factors that modulate the molecular composition of the environment to evoke responses from resident cells. Based on this new insight, current research directions include efforts to