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Research papers on Probiotics and gut health

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  1. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic

    Colin Hill, Francisco Guarner, Gregor Reid, et al. · 2014 · Nature Reviews Gastroenterology & Hepatology · 9,320 citations

    Probiotics are widely regarded as live microorganisms that, when administered in sufficient amounts, confer a health benefit, but guidance is needed on the most appropriate use of the term. This Consensus Statement outlines recommendations for the scope and definition of the term 'probiotic' as determined by an expert panel convened by the International Scientific Association for Probiotics and Prebiotics in October 2013. An expert panel was convened in October 2013 by the International Scientific Association for Probiotics and Prebiotics (ISAPP) to discuss the field of probiotics. It is now 13 years since the definition of probiotics and 12 years after guidelines were published for regulato

  2. The Human Microbiome Project

    Peter J. Turnbaugh, Ruth E. Ley, Micah Hamady, et al. · 2007 · Nature · 6,158 citations

    A strategy to understand the microbial components of the human genetic and metabolic landscape and how they contribute to normal physiology and predisposition to disease.

  5. Influence of diet on the gut microbiome and implications for human health

    Rasnik Singh, Hsin-Wen Chang, Di Yan, et al. · 2017 · Journal of Translational Medicine · 2,624 citations

    Recent studies have suggested that the intestinal microbiome plays an important role in modulating risk of several chronic diseases, including inflammatory bowel disease, obesity, type 2 diabetes, cardiovascular disease, and cancer. At the same time, it is now understood that diet plays a significant role in shaping the microbiome, with experiments showing that dietary alterations can induce large, temporary microbial shifts within 24 h. Given this association, there may be significant therapeutic utility in altering microbial composition through diet. This review systematically evaluates current data regarding the effects of several common dietary components on intestinal microbiota. We sho

  6. Gut microbiome and health: mechanistic insights

    Willem M. de Vos, Herbert Tilg, Matthias Van Hul, et al. · 2022 · Gut · 2,371 citations

    The gut microbiota is now considered as one of the key elements contributing to the regulation of host health. Virtually all our body sites are colonised by microbes suggesting different types of crosstalk with our organs. Because of the development of molecular tools and techniques (ie, metagenomic, metabolomic, lipidomic, metatranscriptomic), the complex interactions occurring between the host and the different microorganisms are progressively being deciphered. Nowadays, gut microbiota deviations are linked with many diseases including obesity, type 2 diabetes, hepatic steatosis, intestinal bowel diseases (IBDs) and several types of cancer. Thus, suggesting that various pathways involved i

  7. Gut microbiome alterations in Alzheimer’s disease

    N. Vogt, Robert L. Kerby, Kimberly A. Dill‐McFarland, et al. · 2017 · Scientific Reports · 2,150 citations

    Alzheimer's disease (AD) is the most common form of dementia. However, the etiopathogenesis of this devastating disease is not fully understood. Recent studies in rodents suggest that alterations in the gut microbiome may contribute to amyloid deposition, yet the microbial communities associated with AD have not been characterized in humans. Towards this end, we characterized the bacterial taxonomic composition of fecal samples from participants with and without a diagnosis of dementia due to AD. Our analyses revealed that the gut microbiome of AD participants has decreased microbial diversity and is compositionally distinct from control age- and sex-matched individuals. We identified phylum

  10. The Effect of Probiotics on the Production of Short-Chain Fatty Acids by Human Intestinal Microbiome

    Paulina Markowiak‐Kopeć, Katarzyna Śliżewska · 2020 · Nutrients · 1,199 citations

    The relationship between diet and the diversity and function of the intestinal microbiome and its importance for human health is currently the subject of many studies. The type and proportion of microorganisms found in the intestines can determine the energy balance of the host. Intestinal microorganisms perform many important functions, one of which is participation in metabolic processes, e.g., in the production of short-chain fatty acids-SCFAs (also called volatile fatty acids). These acids represent the main carbon flow from the diet to the host microbiome. Maintaining intestinal balance is necessary to maintain the host's normal health and prevent many diseases. The results of many stud

  11. Gut Microbiome: Profound Implications for Diet and Disease

    Ronald D. Hills, Benjamin Pontefract, Hillary R. Mishcon, et al. · 2019 · Nutrients · 1,125 citations

    The gut microbiome plays an important role in human health and influences the development of chronic diseases ranging from metabolic disease to gastrointestinal disorders and colorectal cancer. Of increasing prevalence in Western societies, these conditions carry a high burden of care. Dietary patterns and environmental factors have a profound effect on shaping gut microbiota in real time. Diverse populations of intestinal bacteria mediate their beneficial effects through the fermentation of dietary fiber to produce short-chain fatty acids, endogenous signals with important roles in lipid homeostasis and reducing inflammation. Recent progress shows that an individual’s starting microbial pro

  12. Gut microbiome and human health: Exploring how the probiotic genus Lactobacillus modulate immune responses

    Sonakshi Rastogi, Aditi Singh · 2022 · Frontiers in Pharmacology · 318 citations

    The highest density of microbes resides in human gastrointestinal tract, known as “Gut microbiome”. Of note, the members of the genus Lactobacillus that belong to phyla Firmicutes are the most important probiotic bacteria of the gut microbiome. These gut-residing Lactobacillus species not only communicate with each other but also with the gut epithelial lining to balance the gut barrier integrity, mucosal barrier defence and ameliorate the host immune responses. The human body suffers from several inflammatory diseases affecting the gut, lungs, heart, bone or neural tissues. Mounting evidence supports the significant role of Lactobacillus spp. and their components (such as metabolites, pepti

  14. Probiotics in Poultry: Unlocking Productivity Through Microbiome Modulation and Gut Health

    Muhammad Naeem, Dianna Bourassa · 2025 · Microorganisms · 104 citations

    This review explores the role of probiotics in improving productivity and gut health in poultry through microbiome modulation, particularly during early life. Gut health is pivotal to poultry performance, influencing nutrient absorption, immune function, and disease resistance. Early-life interventions target the microbiome to shape long-term health and productivity. Probiotics, live microorganisms providing health benefits, improve gut health through the competitive exclusion of pathogens, immune modulation, antimicrobial compound production, and enhancing gut barrier integrity. Applying probiotics improves growth performance, feed conversion efficiency, body weight gain, and carcass qualit

  16. Gut bioengineered models to study host-microbiota-probiotics interactions

    Elise Delannoy, Alexandre Grassart, Catherine Daniel · 2025 · Microbiome Research Reports · 1 citations

    The gastrointestinal tract is the major ecological niche in which gut microbes interact with epithelial and immune cells to maintain homeostasis in mammals. Moreover, probiotics modulate the gut microbiota and exert various health benefits after oral administration and persistence in the gut. Until now, animal models have been the gold standard for unravelling the mechanisms implicated in host-microbe interactions. However, their translational relevance to clinical trials and the associated ethical concerns underscore the need for alternative models. The emergence of microfluidic organ-on-chip technologies provides promising new alternative models to explore human host-microbe interactions w

  17. Probiotics and Gut Microbiome Health

    Mahendra Pal · 2025 · Nutrition and Food Processing

    Recent years have witnessed the global upsurge in the use of probiotics by people as they realized several health benefits. The health of the gut microbiome contributes to the well-being of the human body and the prevention of some diseases. Probiotics, prebiotics and other beneficial components taken in during a healthy diet help to balance the gut microbiome. The probiotics play a significant role both in the prevention and treatment of stomach and intestinal complaints, mental diseases, COVID-19, cancer, and anemia. Yoghurt is considered as a very good source of probiotics, and it should preferably be consumed in the morning. Probiotics manufactured by several pharmaceuticals, are easily

  23. Role of probiotics and vitamins in maintaining a healthy gut microbiome: recent advances

    Bani Tamber Aeri · 2021 · Indian Journal of Community Health

    While the concept of probiotics is not new, science based approaches to developing targeted probiotic products are a renewed interest. Probiotics and the microbiome is now being considered as having a blueprint of good health, unique to every human.  Along with the well-known and established health benefits like reduced antibiotic associated diarrhoea and colic symptoms, eczema, necrotising enterocolitis, acute paediatric infections like diahorrea and upper respiratory tract infections; probiotics are now considered as beneficial for maintaining mental well-being as well. This new branch of disease management is now termed as Nutritional neuroscience and these beneficial gut bacteria are ref

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