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Research papers on Stem cell therapy

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  2. Adipose-Derived Stem Cells for Regenerative Medicine

    Jeffrey M. Gimble, Adam J. Katz, Bruce A. Bunnell · 2007 · Circulation Research · 2,343 citations

    The emerging field of regenerative medicine will require a reliable source of stem cells in addition to biomaterial scaffolds and cytokine growth factors. Adipose tissue represents an abundant and accessible source of adult stem cells with the ability to differentiate along multiple lineage pathways. The isolation, characterization, and preclinical and clinical application of adipose-derived stem cells (ASCs) are reviewed in this article.

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  3. Adult mesenchymal stem cells for tissue engineering versus regenerative medicine

    Arnold I. Caplan · 2007 · Journal of Cellular Physiology · 1,961 citations

    Adult mesenchymal stem cells (MSCs) can be isolated from bone marrow or marrow aspirates and because they are culture-dish adherent, they can be expanded in culture while maintaining their multipotency. The MSCs have been used in preclinical models for tissue engineering of bone, cartilage, muscle, marrow stroma, tendon, fat, and other connective tissues. These tissue-engineered materials show considerable promise for use in rebuilding damaged or diseased mesenchymal tissues. Unanticipated is the realization that the MSCs secrete a large spectrum of bioactive molecules. These molecules are immunosuppressive, especially for T-cells and, thus, allogeneic MSCs can be considered for therapeutic

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  5. Stem cell-based therapy for human diseases

    Duc M. Hoang, Phuong T. Pham, Trung Q. Bach, et al. · 2022 · Signal Transduction and Targeted Therapy · 1,073 citations

    Recent advancements in stem cell technology open a new door for patients suffering from diseases and disorders that have yet to be treated. Stem cell-based therapy, including human pluripotent stem cells (hPSCs) and multipotent mesenchymal stem cells (MSCs), has recently emerged as a key player in regenerative medicine. hPSCs are defined as self-renewable cell types conferring the ability to differentiate into various cellular phenotypes of the human body, including three germ layers. MSCs are multipotent progenitor cells possessing self-renewal ability (limited in vitro) and differentiation potential into mesenchymal lineages, according to the International Society for Cell and Gene Therapy

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  6. Mesenchymal stem cell-derived extracellular vesicles: novel frontiers in regenerative medicine

    Somayeh Keshtkar, Negar Azarpira, Mohammad Hossein Ghahremani · 2018 · Stem Cell Research & Therapy · 929 citations

    Mesenchymal stem cells (MSCs) are multipotent stem cells that have gained significant attention in the field of regenerative medicine. The differentiation potential along with paracrine properties of MSCs have made them a key option for tissue repair. The paracrine functions of MSCs are applied through secreting soluble factors and releasing extracellular vesicles like exosomes and microvesicles. Extracellular vesicles are predominantly endosomal in origin and contain a cargo of miRNA, mRNA, and proteins that are transferred from their original cells to target cells. Recently it has emerged that extracellular vesicles alone are responsible for the therapeutic effect of MSCs in plenty of anim

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  7. Stem Cell Paracrine Actions and Tissue Regeneration

    Priya R. Baraniak, Todd C. McDevitt · 2009 · Regenerative Medicine · 863 citations

    Stem cells have emerged as a key element of regenerative medicine therapies due to their inherent ability to differentiate into a variety of cell phenotypes, thereby providing numerous potential cell therapies to treat an array of degenerative diseases and traumatic injuries. A recent paradigm shift has emerged suggesting that the beneficial effects of stem cells may not be restricted to cell restoration alone, but also due to their transient paracrine actions. Stem cells can secrete potent combinations of trophic factors that modulate the molecular composition of the environment to evoke responses from resident cells. Based on this new insight, current research directions include efforts to

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  8. Stem Cells: A Revolution in Therapeutics—Recent Advances in Stem Cell Biology and Their Therapeutic Applications in Regenerative Medicine and Cancer Therapies

    Murielle Mimeault, Ralph J. Hauke, Surinder K. Batra · 2007 · Clinical Pharmacology & Therapeutics · 457 citations

    Basic and clinical research accomplished during the last few years on embryonic, fetal, amniotic, umbilical cord blood, and adult stem cells has constituted a revolution in regenerative medicine and cancer therapies by providing the possibility of generating multiple therapeutically useful cell types. These new cells could be used for treating numerous genetic and degenerative disorders. Among them, age-related functional defects, hematopoietic and immune system disorders, heart failures, chronic liver injuries, diabetes, Parkinson's and Alzheimer's diseases, arthritis, and muscular, skin, lung, eye, and digestive disorders as well as aggressive and recurrent cancers could be successfully tr

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  11. Mesenchymal stem cell‐based therapy: a new paradigm in regenerative medicine

    Neeraj Kumar Satija, Vimal Kishor Singh, Yogesh Kumar Verma, et al. · 2009 · Journal of Cellular and Molecular Medicine · 250 citations

    Mesenchymal stem cells (MSCs), adherent fibroblastoid cells, present in bone marrow and many other tissues can be easily isolated and expanded in vitro. They are capable of differentiating into different cell types such as osteoblasts, chondrocytes, adipocytes, cardiomyocytes, hepatocytes, endothelial cells and neuronal cells. Such immense plasticity coupled with their ability to modulate the activity of immune cells makes them attractive for stem cell-based therapy aimed at treating previously incurable disorders. Preclinical studies have reported successful use of MSCs for delivering therapeutic proteins and repairing defects in a variety of disease models. These studies highlighted the in

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  12. Therapeutic Properties of Mesenchymal Stromal/Stem Cells: The Need of Cell Priming for Cell-Free Therapies in Regenerative Medicine

    Vitale Miceli, Matteo Bulati, Gioacchin Iannolo, et al. · 2021 · International Journal of Molecular Sciences · 183 citations

    Mesenchymal stromal/stem cells (MSCs) are multipotent adult stem cells that support homeostasis during tissue regeneration. In the last decade, cell therapies based on the use of MSCs have emerged as a promising strategy in the field of regenerative medicine. Although these cells possess robust therapeutic properties that can be applied in the treatment of different diseases, variables in preclinical and clinical trials lead to inconsistent outcomes. MSC therapeutic effects result from the secretion of bioactive molecules affected by either local microenvironment or MSC culture conditions. Hence, MSC paracrine action is currently being explored in several clinical settings either using a con

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  17. Advances in Stem Cell Therapy: A Hope for Regenerative Medicine

    Naveed Shuja · 2024 · DEVELOPMENTAL MEDICO-LIFE-SCIENCES

    Introduction Regenerative medicine has become a light at the end of the tunnel for countless patients who have suffered from diseases previously considered incurable. Stem cell therapy is central to this revolutionary progress and has already made huge advances in recent years. Stem cells have the potential to regenerate tissues, repair organs, and even modulate immune responses, making them a key to delivering innovative treatments for a broad spectrum of medical conditions. This editorial describes recent progress in stem cell therapy as well as its promise as a regenerative medicine[1]. Stem Cells have unique Properties. Stem cells have unique properties that make them of great value in t

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  18. Stem Cell Therapy in Multiple Sclerosis: Regenerative Treatment for Neurological Repair

    Thomas Faile, Vincent S Gallicchio · 2024 · Stem Cell and Regenerative Medicine

    Multiple sclerosis is a chronic autoimmune and neurodegenerative disease, which primarily affects the central nervous system. The purpose of this study was to collectively evaluate the efficiency and safety of a variety of stem cell therapies in clinical studies concerning multiple sclerosis. The findings of this research investigating the treatment options indicate that stem cell therapy of a variety of types hold promise as a treatment option of MS. The most frequently researched stem cells, MSCs and HSCs, primarily provide reduction in inflammation and uncontrollable immune response, with improvements in remyelination and motor function testing. Additionally, stem cell therapy has led to

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  20. Regenerative Longevity Medicine: Hyperbaric Oxygen Therapy as a Cornerstone for Healthy Aging

    Miguel G Garber · 2025 · Stem Cell and Regenerative Medicine

    Regenerative longevity medicine is revolutionizing healthcare by targeting the biological mechanisms of aging to extend healthspan and improve quality of life. This article critically examines the integration of hyperbaric oxygen therapy (HBOT) into regenerative medicine, emphasizing its role in cellular repair, inflammation reduction, and cognitive enhancement. Despite evidence supporting its efficacy in modulating biological aging markers such as telomere length and cellular senescence, HBOT remains underrepresented in longevity medicine discourse. We argue for the necessity of including HBOT in regenerative strategies and explore its synergistic potential with interventions like stem cell

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  21. Systemic Lupus Erythematosus & Stem Cell Therapy

    Samantha Albano, Vincent S Gallicchio · 2023 · Stem Cell and Regenerative Medicine

    Systemic lupus erythematosus is an autoimmune disease characterized by a diverse range of clinical presentation and severe complications involving multiple organ systems. The global prevalence of this disorder ranges from 13 to 7713.5 per 100 000 individuals, with non-Caucasian women at the highest risk of developing the disease. SLE is a social as well as public health problem as this condition ranks among one of the top twenty leading causes of death in females from the age of five to sixty-four years of age and current treatments using multidisciplinary approaches can only work to control symptoms and further progression of disease while no true cure exists. Recent studies involving stem

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