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Research papers on Vitamin D deficiency

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  4. Vitamin D Deficiency and Outcome of COVID-19 Patients

    Aleksandar Radujkovic, Theresa Hippchen, Shilpa Tiwari‐Heckler, et al. · 2020 · Nutrients · 428 citations

    Infection with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) poses an enormous challenge to health care systems throughout the world. Without causal treatment, identification of modifiable prognostic factors may help to improve outcomes. To explore possible associations of vitamin D (VitD) status with disease severity and survival, we studied 185 patients diagnosed with coronavirus disease 2019 (COVID-19) and treated at our center. VitD status at first presentation was assessed retrospectively using accredited laboratory methods. VitD deficiency was defined as serum total 25-hydroxyvitamin D level < 12 ng/mL (<30 nM). Primary endpoint was severe course of disease (i.e., ne

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  6. Vitamin D Deficiency is a Predictor of Reduced Survival in Patients with Heart Failure; Vitamin D Supplementation Improves Outcome

    Israel Gotsman, Ayelet Shauer, Donna R. Zwas, et al. · 2012 · European Journal of Heart Failure · 199 citations

    AIMS: Vitamin D deficiency is a highly prevalent, global phenomenon. The prevalence in heart failure (HF) patients and its effect on outcome are less clear. We evaluated vitamin D levels and vitamin D supplementation in patients with HF and its effect on mortality. METHODS AND RESULTS: 25-Hydroxyvitamin D [25(OH)D] levels were evaluated in HF patients from a health maintenance organization (HMO), and compared them with those of the rest of the members of the HMO. Patients with HF (n = 3009) had a lower median 25(OH)D level compared with the control group (n = 46 825): 36.9 nmol/L (interquartile range 23.2-55.9) vs. 40.7 nmol/L (26.7-56.9), respectively, P < 0.00001. The percentage of patient

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  7. Vitamin D Metabolism and Guidelines for Vitamin D Supplementation

    Indra Ramasamy · 2020 · Clinical Biochemist Reviews · 192 citations

    Vitamin D is essential for bone health and is known to be involved in immunomodulation and cell proliferation. Vitamin D status remains a significant health issue worldwide. However, there has been no clear consensus on vitamin D deficiency and its measurement in serum, and clinical practice of vitamin D deficiency treatment remains inconsistent. The major circulating metabolite of vitamin D, 25-hydroxyvitamin D (25(OH)D), is widely used as a biomarker of vitamin D status. Other metabolic pathways are recognised as important to vitamin D function and measurement of other metabolites may become important in the future. The utility of free 25(OH)D rather than total 25(OH)D needs further assess

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  8. Recognition and management of vitamin D deficiency.

    Paula Bordelon, Maria V Ghetu, Robert C Langan · 2009 · PubMed · 183 citations

    Vitamin D deficiency affects persons of all ages. Common manifestations of vitamin D deficiency are symmetric low back pain, proximal muscle weakness, muscle aches, and throbbing bone pain elicited with pressure over the sternum or tibia. A 25-hydroxyvitamin D level should be obtained in patients with suspected vitamin D deficiency. Deficiency is defined as a serum 25-hydroxyvitamin D level of less than 20 ng per mL (50 nmol per L), and insufficiency is defined as a serum 25-hydroxyvitamin D level of 20 to 30 ng per mL (50 to 75 nmol per L). The goal of treatment is to normalize vitamin D levels to relieve symptoms and decrease the risk of fractures, falls, and other adverse health outcomes.

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  9. Randomized Controlled Trial (RCT) of Vitamin D Supplementation in Pregnancy in a Population With Endemic Vitamin D Deficiency

    Adekunle H. Dawodu, Hussein Saadi, Gharid Nourallah Bekdache, et al. · 2013 · The Journal of Clinical Endocrinology & Metabolism · 180 citations

    BACKGROUND: Vitamin D (vD) deficiency in pregnancy is a global health problem and the amount of vD supplementation to prevent vD deficiency is controversial. OBJECTIVE: The objective of the study was to determine effectiveness and safety of prenatal 2000 IU and 4000 IU/d compared with 400 IU/d vD3 supplementation in a randomized controlled trial in population in which vD deficiency is endemic. DESIGN/METHODS: Arab women were randomized at 12-16 weeks of gestation to 400, 2000, and 4000 IU/d vD3, which were continued to delivery. Serum 25-hydroxyvitamin D [25(OH)D] concentrations were measured during pregnancy and at delivery. The primary outcome was the maternal and cord blood 25(OH)D, and t

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  11. Vitamin D supplementation for term breastfed infants to prevent vitamin D deficiency and improve bone health

    May Loong Tan, Steven A. Abrams, David Andrew Osborn · 2020 · Cochrane Database of Systematic Reviews · 82 citations

    BACKGROUND: Vitamin D deficiency is common worldwide, contributing to nutritional rickets and osteomalacia which have a major impact on health, growth, and development of infants, children and adolescents. Vitamin D levels are low in breast milk and exclusively breastfed infants are at risk of vitamin D insufficiency or deficiency. OBJECTIVES: To determine the effect of vitamin D supplementation given to infants, or lactating mothers, on vitamin D deficiency, bone density and growth in healthy term breastfed infants. SEARCH METHODS: We used the standard search strategy of Cochrane Neonatal to 29 May 2020 supplemented by searches of clinical trials databases, conference proceedings, and citat

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  12. Vitamin D Deficiency Leads to Poorer Health Outcomes and Greater Length of Stay After Total Knee Arthroplasty and Supplementation Improves Outcomes

    Kavyesh Vivek, Rayan Kamal, Edward Perera, et al. · 2024 · JBJS Reviews · 20 citations

    BACKGROUND: Vitamin D deficiency is increasingly identified as a predictor of poorer outcomes in musculoskeletal disease affecting as many as 1 in 4 people. This study aimed to evaluate the effect of vitamin D supplementation on outcomes after primary total knee arthroplasty (TKA). METHODS: A targeted search of terms related to vitamin D and TKA outcomes was performed in PubMed, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, American Academy of Orthopaedic Surgeons, and British Orthopaedic Association databases. The results were analyzed using forest plots with I2 heterogeneity statistics and pooled effects with 95% confidence intervals (CIs) and p values. A p < 0.05 was

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  16. Asthmatic patients with vitamin D deficiency: Can vitamin D supplementation make a difference

    Haiying Niu, Huijie He, Zilong Zhao, et al. · 2024 · Technology and Health Care · 4 citations

    BACKGROUND: Asthma is a major public health concern due to its persistent inflammation of the airways. The intricate and widely variable epidemiology of asthma among nations and populations is a result of the interplay between genetic, environmental, and socioeconomic factors. OBJECTIVE: This study aims to investigate whether VitD supplementation can reduce the frequency of exacerbations (including the frequency of exacerbations requiring systemic corticosteroids and the frequency of exacerbations necessitating trips to the hospital or emergency room, or both) and improve pulmonary function (clinical indicators such as the FEV1% predicted value). METHODS: Computers were used to search Pubmed

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  19. Supplementation of vitamin D in children with obesity and vitamin D deficiency - review of outcomes in terms of obesity parameters and comorbidities

    Weronika Kamińska, Adrian Bobrzyk, Grzegorz Łyko, et al. · 2023 · Journal of Education, Health and Sport · 2 citations

    In recent years, vitamin D deficiency and obesity in paediatric population have reached epidemic levels worldwide as crucial health concerns with far-reaching consequences. There has been a substantial growth in studies dedicated to these two public health issues over the last years. Numerous studies have confirmed that excess body weight has negative impact on vitamin D metabolism, leading to a higher risk of low levels of this essential vitamin, among individuals who are overweight or obese. Vitamin D deficiency may play a role in the development of obesity-related conditions as insulin resistance, type two diabetes, NAFLD and cardiovascular disease due to anti-inflammatory properties, imp

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  20. Vitamin D supplementation influences the serum lipid profile in the Jordanian population with vitamin D deficiency

    Saad Alfawaeir · 2025 · Nutrición Clínica y Dietética Hospitalaria · 1 citations

    Purpose: To evaluate the association between vitamin D supplementation and changes in lipid profile in a Jordanian population with vitamin D deficiency. Methodology: A total of 95 participants, comprising 35 females aged 15-73 years, were recruited for this prospective investigation and administered vitamin D supplements. Blood specimens were examined for lipid profile characteristics and 25(OH)D3 amounts. Vitamin D supplementation protocole involved the weekly dosing of a single tablet containing 50,000 IU of cholecalciferol for the first four weeks, and bi-weekly medication for the final four weeks. Findings: Before intervention, vitamin D, calcium, total cholesterol, high-density lipoprot

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