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Research papers on Vitamin D deficiency

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  1. The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration

    Alessandro Liberati, Douglas G. Altman, Jennifer Tetzlaff, et al. · 2009 · PLoS Medicine · 27,955 citations

    Systematic reviews and meta-analyses are essential to summarize evidence relating to efficacy and safety of health care interventions accurately and reliably. The clarity and transparency of these reports, however, is not optimal. Poor reporting of systematic reviews diminishes their value to clinicians, policy makers, and other users.Since the development of the QUOROM (QUality Of Reporting Of Meta-analysis) Statement--a reporting guideline published in 1999--there have been several conceptual, methodological, and practical advances regarding the conduct and reporting of systematic reviews and meta-analyses. Also, reviews of published systematic reviews have found that key information about

  2. Induction of the Vitamin D Receptor Attenuates Autophagy Dysfunction-Mediated Cell Death Following Traumatic Brain Injury.

    Changmeng Cui, Jianzhong Cui, Feng Jin, et al. · 2017 · PubMed · 5,191 citations

    BACKGROUND/AIMS: Traumatic brain injury (TBI) is a major public health problem in the world and causes high rates of mortality and disability. Recent evidence suggests that vitamin D (VD) has neuroprotective actions and can promote function recovery after TBI. In vitro and in vivo studies have demonstrated that autophagy could be enhanced following supplementation with an active metabolite of VD (calcitriol). However, it is unclear whether autophagy participates in the protective effects of calcitriol after TBI. To test this hypothesis, we examined the protective effects of calcitriol on TBI-induced neurological impairment and further investigated whether calcitriol could modulate autophagy

  3. The 2011 Report on Dietary Reference Intakes for Calcium and Vitamin D from the Institute of Medicine: What Clinicians Need to Know

    A. Catharine Ross, JoAnn E. Manson, Steven A. Abrams, et al. · 2010 · The Journal of Clinical Endocrinology & Metabolism · 4,057 citations

    This article summarizes the new 2011 report on dietary requirements for calcium and vitamin D from the Institute of Medicine (IOM). An IOM Committee charged with determining the population needs for these nutrients in North America conducted a comprehensive review of the evidence for both skeletal and extraskeletal outcomes. The Committee concluded that available scientific evidence supports a key role of calcium and vitamin D in skeletal health, consistent with a cause-and-effect relationship and providing a sound basis for determination of intake requirements. For extraskeletal outcomes, including cancer, cardiovascular disease, diabetes, and autoimmune disorders, the evidence was inconsis

  4. Vitamin D Deficiency and Risk of Cardiovascular Disease

    Thomas J. Wang, Michael J. Pencina, Sarah L. Booth, et al. · 2008 · Circulation · 2,395 citations

    BACKGROUND: Vitamin D receptors have a broad tissue distribution that includes vascular smooth muscle, endothelium, and cardiomyocytes. A growing body of evidence suggests that vitamin D deficiency may adversely affect the cardiovascular system, but data from longitudinal studies are lacking. METHODS AND RESULTS: We studied 1739 Framingham Offspring Study participants (mean age 59 years; 55% women; all white) without prior cardiovascular disease. Vitamin D status was assessed by measuring 25-dihydroxyvitamin D (25-OH D) levels. Prespecified thresholds were used to characterize varying degrees of 25-OH D deficiency (< 15 ng/mL, < 10 ng/mL). Multivariable Cox regression models were adjusted fo

  5. Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths

    William B. Grant, Henry Lahore, Sharon L. McDonnell, et al. · 2020 · Nutrients · 1,999 citations

    The world is in the grip of the COVID-19 pandemic. Public health measures that can reduce the risk of infection and death in addition to quarantines are desperately needed. This article reviews the roles of vitamin D in reducing the risk of respiratory tract infections, knowledge about the epidemiology of influenza and COVID-19, and how vitamin D supplementation might be a useful measure to reduce risk. Through several mechanisms, vitamin D can reduce risk of infections. Those mechanisms include inducing cathelicidins and defensins that can lower viral replication rates and reducing concentrations of pro-inflammatory cytokines that produce the inflammation that injures the lining of the lung

  6. Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice

    Roger Bouillon, Geert Carmeliet, Lieve Verlinden, et al. · 2008 · Endocrine Reviews · 1,780 citations

    The vitamin D endocrine system is essential for calcium and bone homeostasis. The precise mode of action and the full spectrum of activities of the vitamin D hormone, 1,25-dihydroxyvitamin D [1,25-(OH)(2)D], can now be better evaluated by critical analysis of mice with engineered deletion of the vitamin D receptor (VDR). Absence of a functional VDR or the key activating enzyme, 25-OHD-1alpha-hydroxylase (CYP27B1), in mice creates a bone and growth plate phenotype that mimics humans with the same congenital disease or severe vitamin D deficiency. The intestine is the key target for the VDR because high calcium intake, or selective VDR rescue in the intestine, restores a normal bone and growth

  10. Vitamin D Deficiency Leads to Poorer Health Outcomes and Greater Length of Stay After Total Knee Arthroplasty and Supplementation Improves Outcomes

    Kavyesh Vivek, R. Kamal, E. Perera, et al. · 2024 · Jbjs Reviews · 723 citations

    Background: Vitamin D deficiency is increasingly identified as a predictor of poorer outcomes in musculoskeletal disease affecting as many as 1 in 4 people. This study aimed to evaluate the effect of vitamin D supplementation on outcomes after primary total knee arthroplasty (TKA). Methods: A targeted search of terms related to vitamin D and TKA outcomes was performed in PubMed, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, American Academy of Orthopaedic Surgeons, and British Orthopaedic Association databases. The results were analyzed using forest plots with I2 heterogeneity statistics and pooled effects with 95% confidence intervals (CIs) and p values. A p < 0.05 was

  13. Effects of vitamin D in pregnancy on maternal and offspring health-related outcomes: An umbrella review of systematic review and meta-analyses

    M. Chien, Chueh-Yi Huang, Jie-Huei Wang, et al. · 2024 · Nutrition & Diabetes · 65 citations

    Background Vitamin D deficiency has been linked with several adverse maternal and fetal outcomes. Objective To summarize systematic reviews and meta-analyses evaluating the effects of vitamin D deficiency and of vitamin D supplementation in pregnancy on maternal and offspring health-related outcomes. Methods Prior to conducting this umbrella review, we registered the protocol in PROSPERO (CRD42022368003). We conducted searches in PubMed, Embase, and Cochrane Library for systematic reviews and meta-analyses on vitamin D in pregnancy, from database inception to October 2, 2023. All outcomes related to vitamin D in pregnancy obtained from the systematic reviews and meta-analyses were extracted.

  14. Neurodevelopmental Outcomes in the Offspring of Women with Vitamin D Deficiency and Women Who Received Vitamin D Supplementation During Pregnancy

    Antonia Varthaliti, Kalliopi Rodolaki, Vasilios Lygizos, et al. · 2025 · Nutrients · 8 citations

    Vitamin D is an essential nutrient, involved in various biological processes including calcium homeostasis, bone health, immune function, and brain development. Vitamin D from the mother crosses the placenta during pregnancy, directly impacting the neurodevelopment of the fetus. Vitamin D insufficiency is a substantial global health problem, influencing almost 47.9% of individuals, with especially high predominance rates among pregnant women. Background/Objectives: Preclinical studies suggest that maternal vitamin D deficiency results in significant alterations in the development of the offspring’s brain. Nonetheless, randomized clinical trials in humans have produced conflicting results on

  15. Adverse health outcomes in vitamin D supplementation trials for depression: a systematic review.

    Karen S van den Berg, R. Marijnissen, R.H.S. van den Brink, et al. · 2021 · Ageing research reviews · 8 citations

    BACKGROUND Vitamin D deficiency is a universal risk factor for adverse health outcomes. Since depression is consistently associated with low vitamin D levels as well as several adverse health outcomes, vitamin D supplementation may be especially relevant for depressed persons. This review examines the potential benefits of vitamin D for (somatic) health outcomes in randomised controlled supplementation trials for depression. METHOD Systematic literature search to assess whether adverse health outcomes, such as frailty, falls, or cognitive functioning, were included in vitamin D supplementation trials for depression, and whether these outcomes were affected by supplementation. The revised C

  16. The Real-World Impact of Vitamin D Supplementation on Inflammatory Bowel Disease Clinical Outcomes.

    J. Sninsky, S. Sansgiry, T. Taylor, et al. · 2025 · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 8 citations

    BACKGROUND AND AIMS Vitamin D deficiency is common in inflammatory bowel disease (IBD) and linked to adverse outcomes, yet the therapeutic role of vitamin D supplementation remains uncertain. We evaluated the real-world impact of vitamin D supplementation on corticosteroid use, emergency department (ED) visits, and hospitalizations in patients with IBD. METHODS We conducted a retrospective cohort study of patients with IBD patients seen in the national Veterans Health Administration system from 2000 to 2023. All patients who had a vitamin D lab assay without a vitamin D prescription in the preceding three months were included. We used the quasi-experimental design with difference-in-differ

  18. Effects of Maternal Vitamin D Supplementation on Childhood Health

    Nanna S Svensson, Tabia Volqvartz, A. L. Vestergaard, et al. · 2025 · Endocrine Reviews · 5 citations

    Abstract Vitamin D deficiency during pregnancy is associated with an increased risk of health issues in the offspring. Accordingly, recent Endocrine Society guidelines strongly support supplementation in pregnancy, also underlining that without consensus on optimal maternal vitamin D levels, routine screening is currently irrelevant. Knowledge of organ-specific effects of vitamin D and its association with maternal vitamin D status may aid in optimizing vitamin D supplementation. This systematic review outlines the proposed next-generation effects of vitamin D supplementation ≥400 IU/d and explores whether such effects are attributed to a specific maternal vitamin D level obtained during pre

  21. Asthmatic patients with vitamin D deficiency: Can vitamin D supplementation make a difference

    Haiying Niu, Huijie He, Zilong Zhao, et al. · 2024 · Technology and Health Care · 4 citations

    BACKGROUND: Asthma is a major public health concern due to its persistent inflammation of the airways. The intricate and widely variable epidemiology of asthma among nations and populations is a result of the interplay between genetic, environmental, and socioeconomic factors. OBJECTIVE: This study aims to investigate whether VitD supplementation can reduce the frequency of exacerbations (including the frequency of exacerbations requiring systemic corticosteroids and the frequency of exacerbations necessitating trips to the hospital or emergency room, or both) and improve pulmonary function (clinical indicators such as the FEV1% predicted value). METHODS: Computers were used to search Pubmed

  22. Vitamin D Deficiency and Infantile Rickets Worldwide (2000–2025): Epidemiological Patterns, Public Health Gaps and Interventional Insights

    Ashraf T. Soliman, F. Alyafei, Nada Alaaraj, et al. · 2025 · GSC Advanced Research and Reviews · 3 citations

    Background: Vitamin D deficiency and rickets remain persistent public health challenges affecting infants globally, despite the preventable nature of the condition. Etiology is multifactorial—encompassing limited sun exposure, inadequate maternal and infant nutrition, cultural practices, and insufficient national supplementation programs. Disparities in incidence and outcomes continue to emerge across geographic, socioeconomic, and policy environments. Objectives: To examine global trends in the prevalence of vitamin D deficiency and rickets in infants from 2000 to 2025; to compare the clinical-radiological manifestation of rickets versus subclinical vitamin D deficiency; and to evaluate the

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