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Research papers on HPV vaccine and cancer

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  1. Domestic HPV vaccine price and economic returns for cervical cancer prevention in China: a cost-effectiveness analysis

    Zhuoru Zou, Christopher Kincaid Fairley, Jason J. Ong, et al. · 2020 · The Lancet Global Health · 175 citations

    BACKGROUND: Coinciding with the release of the first Chinese domestic human papillomavirus (HPV) vaccine Cecolin in 2019, and the substantial advancements in cervical cancer screening technology, we aimed to evaluate the cost-effectiveness of the combined strategies of cervical cancer screening programmes and universal vaccination of girls (aged 9-14 years) with Cecolin in China. METHODS: We did a cost-effectiveness analysis in China, in which we developed a Markov model of cervical cancer to evaluate the incremental cost-effectiveness ratios of 61 intervention strategies, including a combination of various screening methods at different frequencies with and without vaccination, and also vac

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  2. Cervical Coinfection with Human Papillomavirus (HPV) Types and Possible Implications for the Prevention of Cervical Cancer by HPV Vaccines

    Fabián Méndez, Núbia Muñóz, Héctor Posso, et al. · 2005 · The Journal of Infectious Diseases · 161 citations

    Coinfection with multiple types of human papillomavirus (HPV) and its implications for the development of efficacious HPV vaccines is a subject of great interest. To describe the occurrence of concurrent infection with multiple HPV types and to determine whether genital HPV infection modifies the risk of acquiring a new HPV infection with another HPV type, 1610 subjects were monitored for an average of 4.1 years in Bogota, Colombia. Information on risk factors for HPV infection and cervical cells was collected for detection of HPV DNA of 36 types at study entry and at 6 consecutive 6-month follow-up visits. Clustering or the concurrent acquisition of multiple types occurred more often than w

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  3. Cervarix™: a vaccine for the prevention of HPV 16, 18-associated cervical cancer

    Tzyy-Choou Wu · 2008 · Biologics · 139 citations

    Cervical cancer continues to be the second largest cause of cancer deaths in women worldwide. Persistent infection with high-risk types of human papillomavirus (HPV) is a necessary cause of cervical cancer. Thus, prophylactic vaccination against HPV is an attractive strategy to prevent cervical cancer. Current strategies for the development of safe and effective preventive vaccines are based on the induction of neutralizing antibodies against the major capsid protein, L1 of HPV. Cervarix() is one of the preventive HPV vaccines that has been approved in the Europe and Australia and is currently under review by the US Food and Drug Administration. Cervarix is composed of HPV16 and HPV18 L1 vir

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  4. A Review on the Use of the HPV Vaccine in the Prevention of Cervical Cancer

    Pranav Pathak, Sandhya Pajai, Himanshi Kesharwani · 2022 · Cureus · 35 citations

    The main risk factor for invasive cervical carcinoma is persistent infection by the high-risk human papillomavirus (HPV). HPV is the most prevalent sexually transmitted infection (STI) and has been linked to 15 different cancers. Cervical cancer is one of the most frequent cancers among women, particularly in resource-limited countries. Cervical cancer is an HPV disease with the highest worldwide burden in resource-limited nations. With improved medical care and nationwide screening programmes, the mortality rate from cervical cancer has decreased in the past 40 years. Many developing nations have been shown to have inadequate knowledge and health-seeking practices, making proper awareness a

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  5. HPV Vaccine: A Breakthrough in Prevention of Cervical Cancer

    Ruchi G. Sharma · 2012 · Apollo Medicine · 11 citations

    Abstract Background Cervical cancer is one of the commonest cancers in women. As it affects young women it has grave personal, social and economic consequences. It is unfortunate that despite cancer cervix being a preventable disease, we have failed to reduce the number of deaths related to it. Recent developments in the understanding of the disease process and its link to the oncogenic strains of Human Papilloma Virus (HPV) has opened new avenues in the way of prevention of cervical cancer. Method The information was collected through literature search using the key words HPV, cancer cervix and prevention. Result It is now well established that almost all cervival cancers are caused by onco

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  6. Role of HPV Vaccine in the Prevention of Cervical Cancer

    Jalal-Eddeen Abubakar Saleh, H Yusuph, Zailani ZB · 2013 · Journal of Interdisciplinary Histopathology · 3 citations

    Background: Cervical cancer which affects relatively young women of child bearing age is considered to be the second most common cancer in women and a leading cause of cancer-related deaths in developing countries, a reflection of global health inequity. There are more than 450,000 newly diagnosed cases annually with over a quarter of million deaths recorded out of which over 80 percent are from the developing countries especially Africa, South Asia, South and Central America, and the Caribbean, with an exponential rise expected from this figure by 2020. The preventive measures available (Pap smear and HPV vaccine) aimed at reducing morbidity and mortality associated with this disease, has b

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  7. Cervical Cancer Prevention: Knowledge, Screening Practices, and HPV Vaccine Awareness among Women in Hyderabad Region, Pakistan

    Saira Dars · 2025 · European Journal of Clinical Pharmacy · 1 citations

    Background: Cervical cancer remains a leading cause of morbidity and mortality among women in low- and middle-income countries. In Pakistan, limited awareness and low vaccination uptake hinder effective prevention. This study assessed women’s knowledge, attitudes, screening practices, and HPV vaccine awareness in the Hyderabad–Jamshoro region of Sindh. Methods: A descriptive cross-sectional survey was conducted among 420 women aged 21–55 years attending gynecology outpatient departments at Liaquat University of Medical & Health Sciences. A structured questionnaire assessed sociodemographic characteristics, cervical cancer and HPV knowledge, Pap smear screening practices, vaccine awareness, a

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  8. Cervical Cancer Prevention with HPV Vaccines

    Chaivanee Kaosayapandhu · 2017 · DOAJ (DOAJ: Directory of Open Access Journals)

    Cervical cancer is the most common malignancy in Thai women with 70% of all cases caused by Human Papillomavirus (HPV) 16, 18 and transmitted by sexual intercourse. Cervical cancer can be prevented by screening tests and HPV vaccines. In Thailand HPV vaccines currently are available in 2 types which are Bivalent, which has HPV 16,18 antigen and AS04 immunizer resulting in high immunization, and Quadrivalent, which has HPV 16,18 antigen and HPV 6,11 antigen which are not the cause of cervical cancer but of genital warts. The result of the study shows the differences of both types of vaccines in immunization mechanism, efficacy, cross-link prevention and indications. Both vaccines are certifie

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  9. An Insight: HPV Vaccine for prevention of cervical cancer

    Vksk Priyanka Kavuluru · 2020 · International Journal of Advance Research in Nursing

    Cervical cancer is preventable because of immunization with human papillomavirus (HPV) Vaccine. Uptake of this vaccine remains low in many countries, although the bivalent and quadrivalent HPV vaccines given as a three-dose schedule are effective in the prevention of precancerous lesions of the cervix in women. Simpler immunization schedules including both male and females are available, which might reduce barriers to vaccination. Currently, licensed two prophylactic vaccines against HPV are in use in most of the countries. It can be added to a comprehensive cervical cancer prevention strategy as a primary prevention tool. Currently available HPV vaccines have an excellent safety profile and

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  10. Reframing the HPV vaccine as cervical cancer prevention

    START Center, Anna Sutton, Sarah Hicks, et al. · 2024

    The START Center performed literature reviews to understand the underlying barriers to parental acceptance of the HPV vaccine for their adolescent daughters aged 9-14 years, assess the relationship between HPV vaccination and increased sexual activity in adolescence, and understand if parental amenability to the HPV vaccine for their daughters changed if the vaccine was aligned with cervical cancer prevention rather than with sexual and reproductive health.

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