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Research papers on HPV vaccine and cancer

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  1. Global cancer statistics

    Ahmedin Jemal, Freddie Bray, Jacques Ferlay, et al. · 2011 · CA A Cancer Journal for Clinicians · 55,092 citations

    The global burden of cancer continues to increase largely because of the aging and growth of the world population alongside an increasing adoption of cancer-causing behaviors, particularly smoking, in economically developing countries. Based on the GLOBOCAN 2008 estimates, about 12.7 million cancer cases and 7.6 million cancer deaths are estimated to have occurred in 2008; of these, 56% of the cases and 64% of the deaths occurred in the economically developing world. Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among females, accounting for 23% of the total cancer cases and 14% of the cancer deaths. Lung cancer is the leading cancer site in male

  2. Cancer statistics, 2019

    Rebecca L. Siegel, Kimberly D. Miller, Ahmedin Jemal · 2019 · CA A Cancer Journal for Clinicians · 21,000 citations

    Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths that will occur in the United States and compiles the most recent data on cancer incidence, mortality, and survival. Incidence data, available through 2015, were collected by the Surveillance, Epidemiology, and End Results Program; the National Program of Cancer Registries; and the North American Association of Central Cancer Registries. Mortality data, available through 2016, were collected by the National Center for Health Statistics. In 2019, 1,762,450 new cancer cases and 606,880 cancer deaths are projected to occur in the United States. Over the past decade of data, the cancer incidence rate (200

  3. Cancer Statistics, 2021

    Rebecca L. Siegel, Kimberly D. Miller, Hannah E. Fuchs, et al. · 2021 · CA A Cancer Journal for Clinicians · 17,432 citations

    Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths in the United States and compiles the most recent data on population-based cancer occurrence. Incidence data (through 2017) were collected by the Surveillance, Epidemiology, and End Results Program; the National Program of Cancer Registries; and the North American Association of Central Cancer Registries. Mortality data (through 2018) were collected by the National Center for Health Statistics. In 2021, 1,898,160 new cancer cases and 608,570 cancer deaths are projected to occur in the United States. After increasing for most of the 20th century, the cancer death rate has fallen continuously from its p

  4. Cancer statistics, 2023

    Rebecca L. Siegel, Kimberly D. Miller, Nikita Sandeep Wagle, et al. · 2023 · CA A Cancer Journal for Clinicians · 16,885 citations

    Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths in the United States and compiles the most recent data on population-based cancer occurrence and outcomes using incidence data collected by central cancer registries and mortality data collected by the National Center for Health Statistics. In 2023, 1,958,310 new cancer cases and 609,820 cancer deaths are projected to occur in the United States. Cancer incidence increased for prostate cancer by 3% annually from 2014 through 2019 after two decades of decline, translating to an additional 99,000 new cases; otherwise, however, incidence trends were more favorable in men compared to women. For example, lu

  5. Epidemiologic Classification of Human Papillomavirus Types Associated with Cervical Cancer

    Núbia Muñóz, F. Xavier Bosch, Sílvia de Sanjosé, et al. · 2003 · New England Journal of Medicine · 6,315 citations

    BACKGROUND: Infection with human papilloma virus (HPV) is the main cause of cervical cancer, but the risk associated with the various HPV types has not been adequately assessed. METHODS: We pooled data from 11 case-control studies from nine countries involving 1918 women with histologically confirmed squamous-cell cervical cancer and 1928 control women. A common protocol and questionnaire were used. Information on risk factors was obtained by personal interviews, and cervical cells were collected for detection of HPV DNA and typing in a central laboratory by polymerase-chain-reaction-based assays (with MY09/MY11 and GP5+/6+ primers). RESULTS: HPV DNA was detected in 1739 of the 1918 patients

  6. Development of Virus-Like Particle Technology from Small Highly Symmetric to Large Complex Virus-Like Particle Structures

    Peter Pushko, Paul Pumpens, Elmars Grens · 2013 · Intervirology · 5,972 citations

    On October 16, 2009, the Food and Drug Administration licensed quadrivalent human papillomavirus vaccine (HPV4; Gardasil, Merck & Co. Inc.) for use in males aged 9 through 26 years for prevention of genital warts caused by human papillomavirus (HPV) types 6 and 11. HPV4 had been licensed previously for use in females aged 9 through 26 years for prevention of HPV 6, 11, 16, and 18-related outcomes (i.e., vaginal, vulvar, and cervical precancers and cancers and genital warts). The Advisory Committee on Immunization Practices (ACIP) recommends routine vaccination of females at age 11 or 12 years and catch-up vaccination for females aged 13 through 26 years. On October 21, 2009, ACIP provided gu

  7. Prevalence of Human Papillomavirus in Cervical Cancer: a Worldwide Perspective

    F. Xavier Bosch, M. Michele Manos, N. Munoz, et al. · 1995 · JNCI Journal of the National Cancer Institute · 3,438 citations

    BACKGROUND: Epidemiologic studies have shown that the association of genital human papillomavirus (HPV) with cervical cancer is strong, independent of other risk factors, and consistent in several countries. There are more than 20 different cancer-associated HPV types, but little is known about their geographic variation. PURPOSE: Our aim was to determine whether the association between HPV infection and cervical cancer is consistent worldwide and to investigate geographic variation in the distribution of HPV types. METHODS: More than 1000 specimens from sequential patients with invasive cervical cancer were collected and stored frozen at 32 hospitals in 22 countries. Slides from all patient

  9. Quadrivalent Vaccine against Human Papillomavirus to Prevent High-Grade Cervical Lesions

    The FUTURE II Study Group · 2007 · New England Journal of Medicine · 2,063 citations

    BACKGROUND: Human papillomavirus types 16 (HPV-16) and 18 (HPV-18) cause approximately 70% of cervical cancers worldwide. A phase 3 trial was conducted to evaluate a quadrivalent vaccine against HPV types 6, 11, 16, and 18 (HPV-6/11/16/18) for the prevention of high-grade cervical lesions associated with HPV-16 and HPV-18. METHODS: In this randomized, double-blind trial, we assigned 12,167 women between the ages of 15 and 26 years to receive three doses of either HPV-6/11/16/18 vaccine or placebo, administered at day 1, month 2, and month 6. The primary analysis was performed for a per-protocol susceptible population that included 5305 women in the vaccine group and 5260 in the placebo group

  16. Cervical Cancer Prevention: Knowledge, Screening Practices, and HPV Vaccine Awareness among Women in Hyderabad Region, Pakistan

    Saira Dars · 2025 · European Journal of Clinical Pharmacy · 1 citations

    Background: Cervical cancer remains a leading cause of morbidity and mortality among women in low- and middle-income countries. In Pakistan, limited awareness and low vaccination uptake hinder effective prevention. This study assessed women’s knowledge, attitudes, screening practices, and HPV vaccine awareness in the Hyderabad–Jamshoro region of Sindh. Methods: A descriptive cross-sectional survey was conducted among 420 women aged 21–55 years attending gynecology outpatient departments at Liaquat University of Medical & Health Sciences. A structured questionnaire assessed sociodemographic characteristics, cervical cancer and HPV knowledge, Pap smear screening practices, vaccine awarenes

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